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Ceftaroline (Teflaro)

 

Ceftaroline

KEY POINTS

  • Ceftaroline (Teflaro) is a cephalosporin and beta-lacatam antibiotic that inhibits the growth of susceptible organisms by interfering with cell wall synthesis
  • Sometimes referred to as a “fifth generation” cephalosporin similar to ceftobiprole
  • The first commercially available beta-lactam in the United States with activity versus MRSA
    • Many people consider ceftaroline to have a spectrum similar to that of ceftriaxone, but with added anti-MRSA coverage
    • DOES NOT cover Pseudomonas aeruginosa
  • Has FDA-indications for skin and soft tissue infection as well as community acquired pneumonia
  • The dose on the label is for BID dosing, but some severe infections can be treated with TID dosing
  • Requires dosage adjustment for renal function once CrCl is below 50 mL/min
  • Has been combined with daptomycin in the treatment of Staphylococcus aureus infections

RESOURCES

  • Ceftaroline Package Insert
  • IDSA Practice Guidelines
  • Ceftaroline Review
  • Ceftaroline: Systematic Review of Clinical Uses and Emerging Drug Resistance (Annals of Pharmacotherapy 2022)


 

Free Antibiotic Cheat Sheet

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