KEY POINTS
- Ceftaroline (Teflaro) is a cephalosporin and beta-lacatam antibiotic that inhibits the growth of susceptible organisms by interfering with cell wall synthesis
- Sometimes referred to as a “fifth generation” cephalosporin similar to ceftobiprole
- The first commercially available beta-lactam in the United States with activity versus MRSA
- Many people consider ceftaroline to have a spectrum similar to that of ceftriaxone, but with added anti-MRSA coverage
- DOES NOT cover Pseudomonas aeruginosa
- Has FDA-indications for skin and soft tissue infection as well as community acquired pneumonia
- The dose on the label is for BID dosing, but some severe infections can be treated with TID dosing
- Requires dosage adjustment for renal function once CrCl is below 50 mL/min
- Has been combined with daptomycin in the treatment of Staphylococcus aureus infections
RESOURCES
- Ceftaroline Package Insert
- IDSA Practice Guidelines
- Ceftaroline Review
- Ceftaroline: Systematic Review of Clinical Uses and Emerging Drug Resistance (Annals of Pharmacotherapy 2022)
