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Sulfamethoxazole-Trimethoprim (Bactrim)

KEY POINTS

  • Sulfamethoxaxole-trimethoprim (Bactrim, Septra, SMX/TMP) is a sulfonamide derivative antibiotic that interferes with bacterial folic acid synthesis and growth by blocking dihydrofolic acid formation from para-aminobenzoic acid.
  • Active against a variety of organisms, including Staphylococcus species, E. coli, Stenotrophamonas maltophilia, Nocardia species, Toxoplasma gondii, Pneumocystis (PCP), and Isospora belli
    • Healthcare associated MRSA is commonly resistant
  • Available as injectable and oral
    • Bactrim SS (single strength) = 400mg SMX + 80mg TMP
    • Bactrim DS (double strength) = 800mg SMX + 160mg TMP
    • Doses vary considerably depending on indication and should be adjusted for renal function
    • Most dosage recommendations are based upon the trimethoprim component
    • Bactrim IV has short expiration once mixed
  • Some of the more concerning or common adverse effects: blood dycrasias, dermatologic reactions, hepatic necrosis, hyperkalemia, hypocalcemia, hyponatermia, hypersensitivity reaction and thrombocytopenia
    • In general the frequency of toxicity increases when drug exposure increases. In particular watch out for hyperkalemia with higher doses

RESOURCES

  • Bactrim Package Insert (oral)
  • Bactrim Package Insert (injectable)
  • Opportunistic Infection Guidelines (AIDSinfo)
  • Infectious Diseases Society of America Guidelines
  • Trimethoprim-associated hyperkalaemia: a systematic review and meta-analysis (JAC 2022)

Free Antibiotic Cheat Sheet

Study Guide

  • Pharmacotherapy Study Guide
  • Acyclovir (Zovirax)
  • Albendazole (Albenza)
  • Amikacin
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  • Baloxavir marboxyl (Xofluza)
  • Bamlanivimab
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  • Bebtelovimab
  • Bezlotoxumab (Zinplava)
  • Brincidofovir (Tembexa)
  • Cantharidin (Ycanth)
  • Casirivimab and Imdevimab (REGEN-COV)
  • Caspofungin (Cancidas)
  • Cefazolin (Ancef)
  • Cefepime (Maxipime)
  • Cefepime-enmetazobactam (Exblifep)
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  • Cefiderocol (Fetroja)
  • Ceftaroline (Teflaro)
  • Ceftazidime (Fortaz, Tazicef)
  • Ceftazidime-avibactam (Avycaz)
  • Ceftobiprole medocaril (Zevtera)
  • Ceftolozane-Tazobactam (Zerbaxa)
  • Ceftriaxone (Rocephin)
  • Cefoxitin (Mefoxin)
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  • Eravacycline (Xerava)
  • Ertapenem (Invanz)
  • Erythromycin
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  • Fecal Microbiota Spores, Live-brpk (Vowst, SER-109)
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  • Ganciclovir (Cytovene)
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  • Glecaprevir/ Pibrentasvir (Mavyret)
  • Ibrexafungerp (Brexafemme)
  • Imipenem-cilastatin (Primaxin)
  • Imipenem-cilastatin-relebactam (Recarbrio)
  • Isavuconazole (Cresemba)
  • Itraconazole (Sporanox)
  • Ivermectin (Stromectol)
  • Ledipasvir/sofosbuvir (Harvoni)
  • Lefamulin (Xenleta)
  • Letermovir (Prevymis)
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  • Linezolid (Zyvox)
  • Maribavir (Livtencity)
  • Meropenem (Merrem)
  • Meropenem-vaborbactam (Vabomere)
  • Metronidazole (Flagyl)
  • Methenamine (Hiprex, Urex)
  • Micafungin (Mycamine)
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  • Moxifloxacin (Avelox)
  • Nafcillin
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  • Omadacycline (Nuzyra)
  • Oritavancin (Orbactiv, Kimyrsa)
  • Oseltamivir (Tamiflu)
  • Oteseconazole (Vivjoa)
  • Oxacillin
  • Nirmatrelvir/ ritonavir (Paxlovid)
  • Penicillin
  • Penicillin Skin Test
  • Phenazopyridine (AZO)
  • Piperacillin-tazobactam (Zosyn)
  • Pivmecillinam (Pivya)
  • Plazomicin (Zemdri)
  • Polymyxin B
  • Posaconazole (Noxafil)
  • Quinupristin-dalfopristin (Synercid)
  • Remdesivir (Veklury)
  • Rezafungin (Rezzayo)
  • Ribavirin
  • Rifabutin (Mycobutin)
  • Rifampin (Rifadin)
  • Secnidazole (Solosec)
  • Sofosbuvir/ velpatasvir/ voxilaprevir (Vosevi)
  • Sulopenem etzadroxil and Probenecid (Orlynvah)
  • Sotrovimab (Xevudy)
  • Sulbactam-durlobactam (Xacduro)
  • Sulfadiazine
  • Sulfamethoxazole-Trimethoprim (Bactrim)
  • Tecovirimat (TPOXX)
  • Tedizolid (Sivextro)
  • Telavancin (Vibativ)
  • Tigecycline (Tygacil)
  • Tobramycin
  • Tocilizumab (Actemra)
  • Valacyclovir (Valtrex)
  • Valganciclovir (Valcyte)
  • Vancomycin
  • Voriconazole (VFend)
  • Zidovudine (Retrovir)
  • Zoster vaccine recombinant, adjuvanted (Shingrix)

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