IDStewardship

  • Home
  • Articles
  • LEARN ANTIBIOTICS
  • Study Guide
  • Resources
  • Q&A
  • #ASPchat
  • Contributors
  • About

Maribavir (Livtencity)

Maribavir photo pending

KEY POINTS

  • Maribavir (Livtencity, TAK-620) is a benzimidazole riboside with activity against cytomegalovirus (CMV)
  • Maribavir works by attaching tho the UL97 encoded serine/tyrosine kinase at the ATP binding site, thus abolishing phototransferase required for a variety of essential viral processes including DNA replication, encapsidation, and nuclear egress
    • Has a unique mechanism of action which limits cross resistance
    • Maribavir can still work against CMV that is resistant to ganciclovir, foscarnet, and/or cidofovir
    • Mutations in UL97 may lead to maribavir resistance
      • CMV DNA levels are recommended to be monitored and resistance should be checked if the patient is not responding to treatment or relapses
  • Maribavir was FDA-approved on 24 November 2021 as the first drug for treating adults and pediatric patients (12 years of age and older and weighing at least 35 kilograms) with post-transplant cytomegalovirus (CMV) infection/disease that does not respond (with or without genetic mutations that cause resistance) to available antiviral treatment for CMV.
    • Maribavir is made by Takeda Pharmaceuticals
  • Approved dosing is 400 mg (two 200 mg tablets) orally twice daily with or without food
  • Maribavir may reduce the antiviral activity of ganciclovir and valganciclovir, so coadministration is not recommended
  • Requires frequent monitoring of monitor immunosuppressant drug levels (e.g., tacrolimus, cyclosporine, sirolimus and everolimus) during and when stopping treatment
    • Maribavir may increase drug concentrations of immunosuppressant drugs that are CYP3A4 and/or P-gp substrates where minimal concentration changes may lead to serious adverse events
  • Does not exhibit myelotoxicity or nephrotoxicity that is problematic with many other CMV drugs
  • Dysgeusia (a bad taste in the mouth) and other GI side effects can be a problematic common side effect of maribavir

RESOURCES

  • Maribavir (Livtencity) Package Insert
  • FDA Approves First Treatment for Common Type of Post-Transplant Infection that is Resistant to Other Drugs
  • Maribivir FDA Briefing Documents – October 2021
  • Letermovir and Maribavir for the Treatment and Prevention of Cytomegalovirus Infection in Solid Organ and Stem Cell Transplant Recipients – CID 2021
  • FDA Advisory Committee Recommends Use of Investigational Drug Maribavir (TAK-620) to Treat Post-Transplant Recipients with Cytomegalovirus (CMV) Infection and Disease Refractory to Treatment With or Without Resistance
  • Maribavir for Preemptive Treatment of Cytomegalovirus Reactivation
  • Letermovir and Maribavir for the Treatment and Prevention of Cytomegalovirus Infection in Solid Organ and Stem Cell Transplant Recipients
  • Maribavir, brincidofovir and letermovir: Efficacy and safety of new antiviral drugs for treating cytomegalovirus infections

Free Antibiotic Cheat Sheet

Study Guide

  • Pharmacotherapy Study Guide
  • Acyclovir (Zovirax)
  • Albendazole (Albenza)
  • Amikacin
  • Aminoglycosides
  • Amphotericin B (Fungizone, Abelcet, Ambisome)
  • Amoxicillin (Amoxil)
  • Amoxicillin-Clavulanic Acid (Augmentin)
  • Ampicillin
  • Ampicillin-sulbactam (Unasyn)
  • Anidulafungin (Eraxis)
  • Artesunate
  • Atovaquone (Mepron)
  • Azithromycin (Zithromax, Zmax)
  • Aztreonam (Azactam, Cayston)
  • Aztreonam-avibactam (Emblaveo)
  • Bacitracin
  • Baloxavir marboxyl (Xofluza)
  • Bamlanivimab
  • Baricitinib (Olumiant)
  • Bebtelovimab
  • Bezlotoxumab (Zinplava)
  • Brincidofovir (Tembexa)
  • Cantharidin (Ycanth)
  • Casirivimab and Imdevimab (REGEN-COV)
  • Caspofungin (Cancidas)
  • Cefazolin (Ancef)
  • Cefepime (Maxipime)
  • Cefepime-enmetazobactam (Exblifep)
  • Cefepime-Taniborbactam
  • Cefiderocol (Fetroja)
  • Ceftaroline (Teflaro)
  • Ceftazidime (Fortaz, Tazicef)
  • Ceftazidime-avibactam (Avycaz)
  • Ceftobiprole medocaril (Zevtera)
  • Ceftolozane-Tazobactam (Zerbaxa)
  • Ceftriaxone (Rocephin)
  • Cefoxitin (Mefoxin)
  • Cephalexin (Keflex)
  • Cidofovir (Vistide)
  • Ciprofloxacin (Cipro)
  • Clarithromycin (Biaxin)
  • Clindamycin (Cleocin)
  • Colistin (colistimethate)
  • Cycloserine (Seromycin)
  • Dalbavancin (Dalvance)
  • Daptomycin (Cubicin)
  • Delafloxacin (Baxdela)
  • Dicloxacillin
  • Doripenem (Doribax)
  • Doxycycline (Doryx)
  • Elbasvir/ grazoprevir (Zepatier)
  • Eravacycline (Xerava)
  • Ertapenem (Invanz)
  • Erythromycin
  • Famciclovir (Famvir)
  • Fecal Microbiota Spores, Live-brpk (Vowst, SER-109)
  • Fidaxomicin (Dificid)
  • Fluconazole (Diflucan)
  • Flucytosine (Ancobon)
  • Foscarnet (Foscavir)
  • Fosfomycin (Monurol)
  • Ganciclovir (Cytovene)
  • Gentamicin (Garamycin)
  • Gepotidacin (Blujepa)
  • Glecaprevir/ Pibrentasvir (Mavyret)
  • Ibrexafungerp (Brexafemme)
  • Imipenem-cilastatin (Primaxin)
  • Imipenem-cilastatin-relebactam (Recarbrio)
  • Isavuconazole (Cresemba)
  • Itraconazole (Sporanox)
  • Ivermectin (Stromectol)
  • Ledipasvir/sofosbuvir (Harvoni)
  • Lefamulin (Xenleta)
  • Letermovir (Prevymis)
  • Levofloxacin (Levaquin)
  • Linezolid (Zyvox)
  • Maribavir (Livtencity)
  • Meropenem (Merrem)
  • Meropenem-vaborbactam (Vabomere)
  • Metronidazole (Flagyl)
  • Methenamine (Hiprex, Urex)
  • Micafungin (Mycamine)
  • Minocycline (Minocin)
  • Molnupiravir (Lagevrio)
  • Moxifloxacin (Avelox)
  • Nafcillin
  • Nitrofurantoin (Macrobid, Macrodantin)
  • Omadacycline (Nuzyra)
  • Oritavancin (Orbactiv, Kimyrsa)
  • Oseltamivir (Tamiflu)
  • Oteseconazole (Vivjoa)
  • Oxacillin
  • Nirmatrelvir/ ritonavir (Paxlovid)
  • Penicillin
  • Penicillin Skin Test
  • Phenazopyridine (AZO)
  • Piperacillin-tazobactam (Zosyn)
  • Pivmecillinam (Pivya)
  • Plazomicin (Zemdri)
  • Polymyxin B
  • Posaconazole (Noxafil)
  • Quinupristin-dalfopristin (Synercid)
  • Remdesivir (Veklury)
  • Rezafungin (Rezzayo)
  • Ribavirin
  • Rifabutin (Mycobutin)
  • Rifampin (Rifadin)
  • Secnidazole (Solosec)
  • Sofosbuvir/ velpatasvir/ voxilaprevir (Vosevi)
  • Sulopenem etzadroxil and Probenecid (Orlynvah)
  • Sotrovimab (Xevudy)
  • Sulbactam-durlobactam (Xacduro)
  • Sulfadiazine
  • Sulfamethoxazole-Trimethoprim (Bactrim)
  • Tecovirimat (TPOXX)
  • Tedizolid (Sivextro)
  • Telavancin (Vibativ)
  • Tigecycline (Tygacil)
  • Tobramycin
  • Tocilizumab (Actemra)
  • Valacyclovir (Valtrex)
  • Valganciclovir (Valcyte)
  • Vancomycin
  • Voriconazole (VFend)
  • Zidovudine (Retrovir)
  • Zoster vaccine recombinant, adjuvanted (Shingrix)

Recent

  • Five Inconvenient Truths To Know About Infectious Diseases
  • Reality Versus Expectation: TikTok As An Educational Tool For Teaching Bugs & Drugs
  • Pharmacy Student Study Strategies To Maximizing Learning In 2025 And Beyond
  • 5 Things To Know About Interpreting MRSA Nares Swab Results
  • Five Tidbits From The Largest International Meeting Of Clinical Microbiologists & Infectious Diseases Specialists In 2025

Search

Copyright 2016-2020 By Charlie Rose, LLC © · IDStewardship.com · Copyright · Privacy Policy · Terms · Contact