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Daptomycin

Daptomycin

KEY POINTS

  • Works by causing depolarization of the cell membrane in sensitive organisms
  • Used to treat infections caused by Gram positive bacteria (e.g., Staph, Strep, Enterococci)
  • Has activity versus most MRSA and VRE, but beware resistance
  • Dose in mg/kg once daily, but reduce to every other day if CrCl < 30 mL/min
  • Beware CPK elevation, myalgias, arthralgias and rhabdomyolysis
    • Monitoring CPK and renal function more than weekly may be necessary in adults with renal impairment per a March 2017 FDA warning
  • DO NOT USE FOR PNEUMONIA – it is inactivated by surfactant in the lung
  • There is a Cubicin RF product of daptomycin that has longer stability and more convenient storage
    • Comparison of Cubicin versus Cubicin RF

RESOURCES

  • Daptomycin Package Insert
  • Eosinophilic Pneumonia FDA Alert
  • MRSA Bloodstream Infection IDstewardship Post
  • Evaluation of a Daptomycin Dose Optimization Protocol
  • Daptomycin From The Mountain To The Clinic – CID
  • The new, new daptomycin breakpoint for Enterococcus spp. – JCM
  • Daptomycin FDA Warnings

Free Antibiotic Cheat Sheet

Study Guide

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