KEY POINTS
- Ampicillin-sulbactam (Unasyn) is the combination of aminopenicillin ampicillin plus beta-lactamase inhibitor sulbactam
- Has activity versus Gram negatives (not Pseudomonas), Gram positives (not MRSA) and anaerobes
- A common drug for human bite wounds (e.g., “fight bite”)
- Common dose is 1.5 gm to 3 gm IV every 6 hours
- Adjust dose/schedule for kidney dysfunction
- Amoxicillin-clavulanic acid is the oral counterpart of ampicillin-sulbactam
RESOURCES