- Imipenem-cilastatin (Primaxin) is a carbapenem and beta-lactam antibiotic
- It kills bacteria in a time-dependent fashion by interfering with the bacterial cell wall in susceptible organisms
- Coverage is broad, including multi-drug resistant Pseudomonas sp. and Acinetobacter sp.
- Has activity versus many atypical Mycobacteria
- Beware seizure risk, especially with higher doses
- Adjust dose/frequency for kidney dysfunction