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Amoxicillin-Clavulanic Acid

Amoxicillin-clavulanic acid aka amoxicillin clavulanate photo

KEY POINTS

  • Amoxicillin-calvulanic acid (Augmentin, amox/clav) is the combination of aminopenicillin amoxicillin plus beta-lactamase inhibitor clavulanic acid (aka clavulanate)
    • Amoxicillin inhibits cell wall synthesis in susceptible organisms via binding to penicillin-binding-proteins (PBPs), while clavulanic acid prevents amoxicillin from being hydrolyzed by beta-lactamases
  • Has activity versus a wide variety of bacteria, including Gram positives, Gram negatives, and anaerobes
    • Covers all the organisms amoxicillin alone covers
    • Compared to amoxicillin alone, it has better anti-anaerobic, anti-Gram negative, and anti-Gram positive coverage
      • Amox/clav has MSSA activity while amoxicillin alone does not
        • Amoxicillin can cover penicillin-susceptible Staph aureus (PSSA)
      • Amox/clav has activity versus Gram negative anaerobes associated with human and animal bite wounds, making it a go-to drug for this indication
      • Does NOT cover Pseudomonas (but piperacillin-tazobactam does)
      • Beware resistance in E. coli
    • Has application for a wide variety of infections including acute otitis media, skin and soft tissue infections, upper respiratory tract infection and more
  • Available oral only in USA, available IV in some other countries
    • Amox/clav’s IV counterpart in USA is ampicillin-sulbactam
  • Available as a pill or suspension
  • Requires dosage adjustment for renal insufficiency
  • Overall safe and well tolerated
    • Beware hypersensitivity reaction and anaphylaxis
    • Note that exposure to aminopenicillins during an Epstein Barr Virus (EBV) infection can result in a non-allergic rash that can physically appear similar to an IgE-mediate allergic reaction
      • This has led to inappropriate penicillin allergy labels, especially in children
      • Penicillin skin testing can assist in ruling out most unclear penicillin allergy labels

RESOURCES

  • Amoxicillin-clavulanic acid (Augmentin) Package Insert
  • 2015 CDC STD Guideline
  • Acute Otitis Media Guideline (AAP 2013)
  • IDSA Practice Guidelines
  • Surgical Prophylaxis Guidelines

Free Antibiotic Cheat Sheet

Study Guide

  • Pharmacotherapy Study Guide
  • Acyclovir
  • Albendazole
  • Amikacin
  • Aminoglycosides
  • Amphotericin B
  • Amoxicillin
  • Amoxicillin-Clavulanic Acid
  • Ampicillin
  • Ampicillin-sulbactam
  • Anidulafungin
  • Artesunate
  • Atovaquone
  • Azithromycin
  • Aztreonam
  • Bacitracin
  • Baloxavir marboxyl (Xofluza)
  • Bamlanivimab
  • Baricitinib
  • Bebtelovimab
  • Bezlotoxumab
  • Brincidofovir
  • Casirivimab and Imdevimab
  • Caspofungin
  • Cefazolin
  • Cefepime
  • Cefiderocol
  • Ceftaroline
  • Ceftazidime
  • Ceftazidime-avibactam
  • Ceftolozane-Tazobactam
  • Ceftriaxone
  • Cefoxitin
  • Cephalexin
  • Cidofovir
  • Ciprofloxacin
  • Clarithromycin
  • Clindamycin
  • Colistin (colistimethate)
  • Cycloserine
  • Dalbavancin
  • Daptomycin
  • Delafloxacin
  • Dicloxacillin
  • Doripenem
  • Doxycycline
  • Elbasvir/ grazoprevir
  • Eravacycline
  • Ertapenem
  • Erythromycin
  • Famciclovir
  • Fidaxomicin
  • Fluconazole
  • Flucytosine
  • Foscarnet
  • Fosfomycin
  • Ganciclovir
  • Gentamicin
  • Glecaprevir/ Pibrentasvir
  • Ibrexafungerp
  • Imipenem-cilastatin
  • Imipenem-cilastatin-relebactam
  • Isavuconazole
  • Itraconazole
  • Ivermectin
  • Ledipasvir/sofosbuvir
  • Lefamulin
  • Letermovir
  • Levofloxacin
  • Linezolid
  • Maribavir (Livtencity)
  • Meropenem
  • Meropenem-vaborbactam
  • Metronidazole
  • Methenamine
  • Micafungin
  • Minocycline
  • Molnupiravir (Lagevrio)
  • Moxifloxacin
  • Nafcillin
  • Nitrofurantoin
  • Omadacycline
  • Oritavancin
  • Oseltamivir
  • Oteseconazole (Vivjoa)
  • Oxacillin
  • Paxlovid (nirmatrelvir/ ritonavir)
  • Penicillin
  • Penicillin Skin Test
  • Phenazopyridine
  • Piperacillin-tazobactam
  • Plazomicin
  • Polymyxin B
  • Posaconazole
  • Quinupristin-dalfopristin
  • Remdesivir (Veklury)
  • Ribavirin
  • Rifabutin
  • Rifampin
  • Secnidazole
  • Sofosbuvir/ velpatasvir/ voxilaprevir
  • Sotrovimab (Xevudy)
  • Sulfadiazine
  • Sulfamethoxazole-Trimethoprim (Bactrim)
  • Tedizolid
  • Telavancin
  • Tigecycline
  • Tobramycin
  • Tocilizumab
  • Valacyclovir
  • Valganciclovir
  • Vancomycin
  • Voriconazole
  • Zidovudine
  • Zoster vaccine recombinant, adjuvanted (Shingrix)

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