IDStewardship

  • Home
  • Articles
  • LEARN ANTIBIOTICS
  • Study Guide
  • Resources
  • Q&A
  • #ASPchat
  • Contributors
  • About

Ciprofloxacin

Ciprofloxacin oral

Ciprofloxacin IV

KEY POINTS

  • Ciprofloxacin (Cipro) is a fluoroquinolone antibiotic that interferes with bacterial DNA synthesis in susceptible organisms by inhbiting DNA gyrase (topoisomerase II) and topoisomerase IV
  • Possesses activity versus a variety of Gram negative bacilli, including Pseudomonas aeruginosa
    • One of the few oral antibiotics with activity versus Pseudomonas sp.
  • Ciprofloxacin is NOT Considered a “respiratory fluoroquinolone” because of its limited activity versus Streptococcus pneuamoniae as compared to other fluoroquinolones
    • Note that ciprofloxacin achieves decent concentrations in the lungs
  • Should generally be avoided for Enterococcus sp. or Staphylococcus sp. due to resistance issues
  • Possesses activity versus atypical organisms such as Legionella sp. and Mycoplasma sp.
  • Available in oral and injectable formulations
    • Oral formulation will bind to cations (e.g., calcium) so do not administer concomitantly with milk, calcium carbonate or other things that may bind to levofloxacin and prevent its absorption
  • Adjust dose for renal impairment
    • 80% bioavailable
  • A common drug to consider for the treatment of prostatitis due to it’s ability to penetrate the prostate (and activity versus E. coli)
  • Per FDA, should only be used when benefits outweigh potential risks if treating acute sinusitis, acute bronchitis or uncomplicated urinary tract infections
  • FDA boxed warnings: tendonitis, tendon rupture, CNS effects, peripheral neuropathy, can worsen existing myasthenia gravis
  • FDA warnings: hypoglycemia (including coma), altered mental health, aortic dissection
  • Other ADRs to beware: QTC prolongation, photosensitivitity
    • Suicidal thoughts added to drug safety label warning by the FDA in February 2017

RESOURCES

  • Oral Ciprofloxacin Package Insert
  • IV Ciprofloxacin Package Insert
  • IDSA Practice Guidelines
  • CDC Sexually Transmitted Diseases Guidelines (2015)
  • Guidelines From AIDSinfo.NIH.gov
  • Mayo Clinic Proceedings Fluoroquinolone Review 1999
  • Collateral Dammage Fluoroquinolones
  • Fluoroquinolone Black Boxed Warnings Viewpoint (2016)


 

Free Antibiotic Cheat Sheet

Study Guide

  • Pharmacotherapy Study Guide
  • Acyclovir
  • Albendazole
  • Amikacin
  • Aminoglycosides
  • Amphotericin B
  • Amoxicillin
  • Amoxicillin-Clavulanic Acid
  • Ampicillin
  • Ampicillin-sulbactam
  • Anidulafungin
  • Artesunate
  • Atovaquone
  • Azithromycin
  • Aztreonam
  • Bacitracin
  • Baloxavir marboxyl (Xofluza)
  • Bamlanivimab
  • Baricitinib
  • Bebtelovimab
  • Bezlotoxumab
  • Brincidofovir
  • Casirivimab and Imdevimab
  • Caspofungin
  • Cefazolin
  • Cefepime
  • Cefiderocol
  • Ceftaroline
  • Ceftazidime
  • Ceftazidime-avibactam
  • Ceftolozane-Tazobactam
  • Ceftriaxone
  • Cefoxitin
  • Cephalexin
  • Cidofovir
  • Ciprofloxacin
  • Clarithromycin
  • Clindamycin
  • Colistin (colistimethate)
  • Cycloserine
  • Dalbavancin
  • Daptomycin
  • Delafloxacin
  • Dicloxacillin
  • Doripenem
  • Doxycycline
  • Elbasvir/ grazoprevir
  • Eravacycline
  • Ertapenem
  • Erythromycin
  • Famciclovir
  • Fidaxomicin
  • Fluconazole
  • Flucytosine
  • Foscarnet
  • Fosfomycin
  • Ganciclovir
  • Gentamicin
  • Glecaprevir/ Pibrentasvir
  • Ibrexafungerp
  • Imipenem-cilastatin
  • Imipenem-cilastatin-relebactam
  • Isavuconazole
  • Itraconazole
  • Ivermectin
  • Ledipasvir/sofosbuvir
  • Lefamulin
  • Letermovir
  • Levofloxacin
  • Linezolid
  • Maribavir (Livtencity)
  • Meropenem
  • Meropenem-vaborbactam
  • Metronidazole
  • Methenamine
  • Micafungin
  • Minocycline
  • Molnupiravir (Lagevrio)
  • Moxifloxacin
  • Nafcillin
  • Nitrofurantoin
  • Omadacycline
  • Oritavancin
  • Oseltamivir
  • Oteseconazole (Vivjoa)
  • Oxacillin
  • Paxlovid (nirmatrelvir/ ritonavir)
  • Penicillin
  • Penicillin Skin Test
  • Phenazopyridine
  • Piperacillin-tazobactam
  • Plazomicin
  • Polymyxin B
  • Posaconazole
  • Quinupristin-dalfopristin
  • Remdesivir (Veklury)
  • Ribavirin
  • Rifabutin
  • Rifampin
  • Secnidazole
  • Sofosbuvir/ velpatasvir/ voxilaprevir
  • Sotrovimab (Xevudy)
  • Sulfadiazine
  • Sulfamethoxazole-Trimethoprim (Bactrim)
  • Tedizolid
  • Telavancin
  • Tigecycline
  • Tobramycin
  • Tocilizumab
  • Valacyclovir
  • Valganciclovir
  • Vancomycin
  • Voriconazole
  • Zidovudine
  • Zoster vaccine recombinant, adjuvanted (Shingrix)

Recent

  • Reality Versus Expectation: Being a Specialty Pharmacist
  • Dessert Before Dinner: How To Sweeten Up Pharmacy Topic Discussions For Your Learners 
  • 5 Tips For Advancing Your Antimicrobial Stewardship Practice
  • How To Build A Blog Post
  • Musical Chairs & The ABCs of SARS-CoV-2 Monoclonal Antibodies

Search

Copyright 2016-2020 By Charlie Rose, LLC © · IDStewardship.com · Copyright · Privacy Policy · Terms · Contact