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Ceftolozane-Tazobactam

KEY POINTS

  • Ceftolozane-tazobactam (Zerbaxa) is the combination of cephalosporin ceftolozane plus beta-lactamase inhibitor tazobactam
    • Has activity versus Pseudomonas aeruginosa 
      • Is thought to be better than ceftazidime-avibactam for multidrug-resistant Pseudomonas aeruginiosa, because ceftolozane-taezobactam’s structure allows for greater bacterial membrane permeability and more stability versus AmpC beta-lactamases
    • Does NOT have activity versus MRSA or VRE
    • Generally a drug people look to for drug-resistant Gram negatives, especially drug-resistant Pseudomonas aeruginosa
  • Ceftolozane-tazobactam was FDA-approved December 19th, 2014
    • Complicated intra-abdominal infection (cIAI) in adults, used in combination with metronidazole
      • December 19th, 2014
    • Complicated urinary tract infection (cUT), including pyelonephritis
      • December 19th, 2014
    • Hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP)
      • June 3rd, 2019
  • Typical dose is 1.5gm IV Q8H for cIAI or cUTI and typical dose is 3gm IV Q8H for HABP or VABP
    • Adjust dose for renal function (CrCl < 50 mL/min)
    • No adjustment for hepatic dysfunction per package insert
  • Beware allergic reaction, renal toxicity, nausea, diarrhea, vomiting amidst other potential side effects
  • Brand name only and fairly expensive

RESOURCES

  • Ceftolozane-tazobactam Package Insert
  • FDA Warning About Zerbaxa Dosing Confusion
  • Ceftolozane-Tazobactam Review (Pharmacotherapy 2015)
  • Ceftazidime/Avibactam and Ceftolozane/Tazobactam: Second-generation β-Lactam/β-Lactamase Inhibitor Combinations (Clin Infect Dis 2016)
  • Insights On Multidrug-Resistant Pseudomonas
  • IDSA Guidelines


 

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