KEY PONTS
- Cefazolin (Ancef) is an injectable first-generation cephalosporin and beta-lactam antibiotic that interferes with bacterial cell wall synthesis in sensitive organisms
- Has activity versus some Gram positive organisms (e.g., Strep. species, methicillin-sensitive Staphylococcus aureus [MSSA])
- VERY commonly used for it’s MSSA coverage
- Since MSSA lives on the skin, cefazolin a common drug to use for surgical prophylaxis – this drug “flows like water” in operating rooms
- Use higher doses in larger size patients (see guideline)
- Since MSSA lives on the skin, cefazolin a common drug to use for surgical prophylaxis – this drug “flows like water” in operating rooms
- VERY commonly used for it’s MSSA coverage
- Has activity versus Gram negative organisms: “PEcK” –> Proteus, E. coli, Klebsiella
- Generally, not considered to have any anaerobic or Enterococcal coverage
- Has activity versus some Gram positive organisms (e.g., Strep. species, methicillin-sensitive Staphylococcus aureus [MSSA])
- Can infused over various durations, including IV push (over 5 minutes), continuous infusion (over 24 hours) or other
- Requires dosage adjustment for renal function
- One strategy used in HD is to do 2/2/3 –> 2gm post-HD Monday, 2gm post-HD Wednesday, then 3gm post-HD on Friday to last the weekend and repeat
RESOURCES