IDStewardship

  • Home
  • Articles
  • Study Guide
  • Resources
  • Practice Tests
  • #ASPchat
  • Contributors
  • About

Sofosbuvir/ velpatasvir/ voxilaprevir

Here is a helpful tip for these new hepatitis C virus drugs:

KEY POINTS

  • Sofosbuvir/ velpatasvir/ voxilaprevir (Vosevi, SOF/VEL/VOX) is the combination of three direct-acting antivirals that work against hepatitis C virus (HCV)
      • Sofosbuvir is a NS5B-inhibitor. It inhibits HCV  NS5B RNA-dependent RNA polymerase, which is an enzyme needed for viral replication.
      • Velpatasvir is an NS5A-inhibitor. It inhibits HCV replication by blocking NS5A protein.
      • Voxilaprevir is a NS3/4A protease inhibitor. It interferes with proteolytic cleavage of HCV.
  • FDA-approved in July 2017 for:
    • Re-treatment of patients with chronic HCV infection in adults due to genotype 1 through 6 previously treated with an NS5A-containing regimen
    • Patients with genotype 1a or 3 previously treated with a sofosbuvir-containing regimen without an NS5A-inhibitor
  • Single tablet taken once daily
    • Sofosbuvir 400 mg + velpatasvir 100 mg + voxilaprevir 100 mg
  • Duration and regimen selection for HCV treatment will typically include: genotype (and resistance), cirrhosis status, and treatment history
    • Common treatment duration is 12 weeks
    • Patients should receive proper screening prior to initiating therapy
  • Common side effects to beware include: diarrhea, fatigue, headache, and nausea
  • FDA Boxed Warning: beware hepatitis B virus reactivition in patients undergoing HCV therapy with direct-acting antivirals
  • Beware drug-drug interactions
    • P-gp inducers, CYP-2B6 inducers, CYP-2C8  inducers and CYP-3A4 inducers may reduce sofosbuvir/ velpatasvir/ voxilaprevir concentrations
      • Contraindicated with rifampin use
  • Beware serious bradycardia if administered with amiodarone
  • While a cost is not available as of yet, it can be expected that this drug will be very expensive

RESOURCES

  • Sofosbuvir/ velpatasvir/ voxilaprevir (Vosevi) Package Insert
  • FDA Announcement of Vosevi Approval
  • Gilead Press Release on Vosevi Approval
  • HCV Treatment Guidelines (American Association For The Study Of Liver Diseases)
  • Provision Of Clinical Pharmacist Services For Individuals With Chronic Hepatitis C Viral Infection (Pharmacotherapy 2014)
  • Sofosbuvir, Velpatasvir and Voxilaprevir combination for the treatment of hepatitis C (2017)
  • Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection (2017)
    • When DAA Treatment for Hepatitis C Fails, 3-Drug Regimen “Highly Effective” (2017)




Sponsored Advertisement

Study Guide

  • Pharmacotherapy Study Guide
  • Acyclovir
  • Albendazole
  • Amikacin
  • Aminoglycosides
  • Amphotericin B
  • Amoxicillin
  • Ampicillin
  • Ampicillin-sulbactam
  • Anidulafungin
  • Atovaquone
  • Azithromycin
  • Aztreonam
  • Bacitracin
  • Bezlotoxumab
  • Caspofungin
  • Cefazolin
  • Cefepime
  • Ceftaroline
  • Ceftazidime
  • Ceftazidime-avibactam
  • Ceftolozane-Tazobactam
  • Ceftriaxone
  • Cefoxitin
  • Cephalexin
  • Ciprofloxacin
  • Clarithromycin
  • Clindamycin
  • Colistin (colistimethate)
  • Cycloserine
  • Dalbavancin
  • Daptomycin
  • Delafloxacin
  • Dicloxacillin
  • Doripenem
  • Doxycycline
  • Elbasvir/ grazoprevir
  • Ertapenem
  • Erythromycin
  • Famciclovir
  • Fidaxomicin
  • Fluconazole
  • Flucytosine
  • Foscarnet
  • Fosfomycin
  • Ganciclovir
  • Gentamicin
  • Glecaprevir/ Pibrentasvir
  • Imipenem-cilastatin
  • Isavuconazole
  • Itraconazole
  • Ivermectin
  • Ledipasvir/sofosbuvir
  • Letermovir
  • Levofloxacin
  • Linezolid
  • Meropenem
  • Meropenem-vaborbactam
  • Metronidazole
  • Methenamine
  • Micafungin
  • Minocycline
  • Moxifloxacin
  • Nafcillin
  • Nitrofurantoin
  • Oritavancin
  • Oseltamivir
  • Oxacillin
  • Penicillin
  • Penicillin Skin Test
  • Phenazopyridine
  • Piperacillin-tazobactam
  • Polymyxin B
  • Posaconazole
  • Quinupristin-dalfopristin
  • Ribavirin
  • Rifabutin
  • Rifampin
  • Secnidazole
  • Sofosbuvir/ velpatasvir/ voxilaprevir
  • Sulfadiazine
  • Sulfamethoxazole-Trimethoprim (Bactrim)
  • Tedizolid
  • Telavancin
  • Tigecycline
  • Tobramycin
  • Valacyclovir
  • Valganciclovir
  • Vancomycin
  • Voriconazole
  • Zidovudine
  • Zoster vaccine recombinant, adjuvanted (Shingrix)

Recent

  • A Study List For Pharmacy Students: Antibiotics That Can Cover Pseudomonas and/or MRSA
  • When Is Dual Beta-Lactam Therapy Appropriate?
  • Basic Tips & Strategies For Managing Emails As A Pharmacy Student, Pharmacy Resident, And Pharmacist
  • Five Important Things To Know About Hospital Antibiograms
  • 4th Annual Northeastern University School of Pharmacy 5K: Run From Resistance

Search

Copyright © 2018 · IDStewardship.com · Terms · Contact