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Erythromycin

KEY POINTS

  • Erythromycin is a macrolide antibiotic that interferes with the growth of susceptible bacteria by inhibiting RNA-dependent protein synthesis at the chain elongation step
    • Binds to the 50S ribosomal subunit, which blocks transpeptidation
  • Available oral, injectable, topical and ophthalmic
  • Has activity versus a variety of bacteria, but is not commonly used today
    • Clarithromycin has less GI effects than erythromycin
    • Azithromycin has less GI side effects and less drug-interactions than erythromycin or clarithromycin
  • Is a motilin-agonist and is used off-label for gastroparesis
  • The different products have different absorption
    • 400mg ethylsuccinate gives the same serum levels as 250mg base or erythromycin stearate
  • Ophthalmic erythromycin is used for prophylaxis versus Neisseria gonorrhoeae and Chlamydia trachomatis

RESOURCES

  • Erythromycin Ethylsuccinate Oral Package Insert
  • Erythromycin Oral Solution Package Insert
  • Erythromycin Delayed-Release Capsule Package Insert
  • Erythromycin Lactobionate Intravenous Package Insert
  • IDSA Guidelines
  • CDC Sexually Transmitted Diseases Guidelines
  • Mayo Clinic Macrolide Review (1999)
  • Macrolide Review (2011)

Free Antibiotic Cheat Sheet

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