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Ceftazidime-avibactam (Avycaz)

[ceftazidime-avibactam photo]

KEY POINTS

  • Ceftazidime-avibactam (Avycaz) is the combination of (1) beta-lactam and third generation cephalosporin ceftazidime PLUS (2) beta-lactamase inhibitor avibactam
    • Ceftazidime interferes with cell wall synthesis through binding to penicillin-binding-proteins
    • Avibactam inactivates some beta-lactamses, which protects ceftazidime from degradation and expands the spectrum of ceftazidime
  • First FDA-approved in February 2015 and indications now include:
    • Complicated intra-abdominal infections, used with metronidazole
    • Complicated urinary tract infection, including pyelonephritis
    • Hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia
  • Has activity versus a variety of multi-drug resistant Gram negative organisms
    • Active versus Pseudomonas aeruginosa
    • Can be active against carbapenem-resistant organisms
      • Sometimes added to other drugs so that the avibactam can be active. For example as aztreonam-ceftazidime-avibactam for treating NDM-producing Gram negative bacteria
    • Does not cover Gram positive organisms methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococci (VRE)
  • Common dose is 2.5gm IV three times per day
    • Adjust doses for kidney function
    • No hepatic dose adjustment listed in package insert
  • Beware hypersensitivity reaction, anxiety, constipation, dizziness, diarrhea, CNS effects
  • A high cost antibiotic that is only available as a branded product

RESOURCES

  • Ceftazidime-avibactam Package Insert
  • IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 2.0
  • Ceftazidime/Avibactam and Ceftolozane/Tazobactam: Second-generation β-Lactam/β-Lactamase Inhibitor Combinations (Clin Infect Dis 2016)
  • Gram Negative Resistance Mechanisms: A Leading Pharmacist’s Clinical Perspectives On AmpC, ESBL and KPC (2017)
  • Insights On Multidrug-Resistant Pseudomonas (2017)
  • Focus On Acinetobacter: An Antibiotic Nightmare (2017)
  • Top 5 Unanswered Questions: The Management Of Invasive Infections Due To Multidrug Resistant Gram-Negative Bacteria (2016)

Photo source: www.avycaz.com



 

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