IDStewardship

  • Home
  • Articles
  • LEARN ANTIBIOTICS
  • Study Guide
  • Resources
  • Q&A
  • #ASPchat
  • Contributors
  • About

Doripenem

[Doripenem photo]

KEY POINTS

  • Doripenem (Doribax) is an injectable carbapenem and beta-lactam antibiotic that interferes with bacterial cell wall synthesis in sensitive organisms
  • Use is commonly reserved for infections due to drug-resistant Gram negative bacteria such as Pseudomonas aeruginosa, Klebsiella pneumoniae, and E. coli
    • Doripenem is believed to have enhanced activity versus Pseudomonas aeruginosa, however promising in vitro data has not translated into better clinical outcomes as compared to other anti-pseudomonal carbpanems (i.e., meropenem and imipenem-cilastatin)
    • DOES NOT cover MRSA or VRE
    • Carbapenems like doripenem are generally considered the drugs of choice for ESBL-producing organisms (aka ESBL-positive organisms)
      • ESBL = extended-spectrum beta-lactmase
    • Reserve this “big gun” antibiotic until you absolutely have to use it
  • Holds FDA-approval for:
    • Complicated intra-abdominal infection
    • Complicated urinary tract infections, including pyelonephritis
  • Typical dose is 500mg every 8 hours in adults
    • Adjust doses when kidney function is below creatinine clearance of 50 mL/min
  • Patients who are allergic to penicillins or cephalosporins may also be allergic to carbapenems
    • Generally speaking cross-reactivity is low, be more concerned in patients with a history of severe allergic reaction
  • Beware seizures and hypersensitivity
  • Beware drug interaction with valproic acid, as doripenem can reduce valproic acid concentrations
  • Hospital commonly carry meropenem or doripenem, but not both

RESOURCES

  • Doripenem Package Insert
  • Recent updates of carbapenem antibiotics (European Journal of Medicinal Chemistry, 2017)
  • Carbapenems: past, present, and future (Antimicrobial Agents and Chemotherapy, 2011)
  • Safety of high-dose doripenem in adult patients with cystic fibrosis (Therapeutic Advances in Drug Safety, 2016)
  • Doripenem: a new carbapenem antibiotic (American Journal of Health-System Pharmacy, 2011)

Free Antibiotic Cheat Sheet

Study Guide

  • Pharmacotherapy Study Guide
  • Acyclovir (Zovirax)
  • Albendazole (Albenza)
  • Amikacin
  • Aminoglycosides
  • Amphotericin B (Fungizone, Abelcet, Ambisome)
  • Amoxicillin (Amoxil)
  • Amoxicillin-Clavulanic Acid (Augmentin)
  • Ampicillin
  • Ampicillin-sulbactam (Unasyn)
  • Anidulafungin (Eraxis)
  • Artesunate
  • Atovaquone (Mepron)
  • Azithromycin (Zithromax, Zmax)
  • Aztreonam (Azactam, Cayston)
  • Bacitracin
  • Baloxavir marboxyl (Xofluza)
  • Bamlanivimab
  • Baricitinib (Olumiant)
  • Bebtelovimab
  • Bezlotoxumab (Zinplava)
  • Brincidofovir (Tembexa)
  • Casirivimab and Imdevimab (REGEN-COV)
  • Caspofungin (Cancidas)
  • Cefazolin (Ancef)
  • Cefepime
  • Cefiderocol
  • Ceftaroline
  • Ceftazidime
  • Ceftazidime-avibactam
  • Ceftolozane-Tazobactam
  • Ceftriaxone
  • Cefoxitin
  • Cephalexin
  • Cidofovir
  • Ciprofloxacin
  • Clarithromycin
  • Clindamycin
  • Colistin (colistimethate)
  • Cycloserine
  • Dalbavancin
  • Daptomycin
  • Delafloxacin
  • Dicloxacillin
  • Doripenem
  • Doxycycline
  • Elbasvir/ grazoprevir
  • Eravacycline
  • Ertapenem
  • Erythromycin
  • Famciclovir
  • Fidaxomicin
  • Fluconazole
  • Flucytosine
  • Foscarnet
  • Fosfomycin
  • Ganciclovir
  • Gentamicin
  • Glecaprevir/ Pibrentasvir
  • Ibrexafungerp
  • Imipenem-cilastatin
  • Imipenem-cilastatin-relebactam
  • Isavuconazole
  • Itraconazole
  • Ivermectin
  • Ledipasvir/sofosbuvir
  • Lefamulin
  • Letermovir
  • Levofloxacin
  • Linezolid
  • Maribavir (Livtencity)
  • Meropenem
  • Meropenem-vaborbactam
  • Metronidazole
  • Methenamine
  • Micafungin
  • Minocycline
  • Molnupiravir (Lagevrio)
  • Moxifloxacin
  • Nafcillin
  • Nitrofurantoin
  • Omadacycline
  • Oritavancin
  • Oseltamivir
  • Oteseconazole (Vivjoa)
  • Oxacillin
  • Paxlovid (nirmatrelvir/ ritonavir)
  • Penicillin
  • Penicillin Skin Test
  • Phenazopyridine
  • Piperacillin-tazobactam
  • Plazomicin
  • Polymyxin B
  • Posaconazole
  • Quinupristin-dalfopristin
  • Remdesivir (Veklury)
  • Ribavirin
  • Rifabutin
  • Rifampin
  • Secnidazole
  • Sofosbuvir/ velpatasvir/ voxilaprevir
  • Sotrovimab (Xevudy)
  • Sulfadiazine
  • Sulfamethoxazole-Trimethoprim (Bactrim)
  • Tedizolid
  • Telavancin
  • Tigecycline
  • Tobramycin
  • Tocilizumab
  • Valacyclovir
  • Valganciclovir
  • Vancomycin
  • Voriconazole
  • Zidovudine
  • Zoster vaccine recombinant, adjuvanted (Shingrix)

Recent

  • Five Common Financial Mistakes To Avoid As A Pharmacist
  • Five Things I Learned From #ASMicrobe 2022 – Through Twitter
  • Going From A To Z With Antibiotic Toxicities
  • IV Push Antibiotics: Practical Insights & Tips From The Front Lines
  • Reality Versus Expectation: Being a Specialty Pharmacist

Search

Copyright 2016-2020 By Charlie Rose, LLC © · IDStewardship.com · Copyright · Privacy Policy · Terms · Contact