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Isavuconazole

KEY POINTS

  • Isavuconazole (isavuconazonium sulfate, Cresemba) is an Az0le antifungal that works by inhibiting the synthesis of ergosterol, a key part of the fungal cell wall
    • Is administered as isavuconazonium sulfate, which is a prodrug, converting to isavuconazole in the blood
  • Has activity versus a number of fungal pathogens, with notable uses for invasive aspergillosis and invasive mucormycosis
  • Available as oral and injectable
    • Intravenous product should not be infused via bolus
  • Dose in milligrams of isavuconazonium sulfate
    • No dosage adjustment provided by package insert for renal or hepatic impairment, but use with caution in child-pugh class C
  • Beware drug-drug interactions
    • Substrate: CYP-3A4 (major)
    • Inhibitor: CYP-2C19 (weak), CYP2C9 (weak), CYP-3A4 (moderate), OCT2
    • Inducer: CYP-2B6 (weak), CYP-2C9 (weak/moderate)
  • Beware hepatic effects and infusion-mediated reactions
  • Some of the more frequent adverse effects to beware include peripheral edema, headache, insomnia, hypokalemia, nausea, vomiting, diarrhea, abdominal pain, constipation, increased liver enzymes, dyspnea and cough

RESOURCES

  • Isavuconazole Package Insert
  • Isavuconazole: A New Triazole Antifungal Agent (CID, 2015)
  • IDSA Aspergillosis Guidelines

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