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Gentamicin

KEY POINTS

  • Gentamicin is an aminoglycoside antibiotic that inhibits bacterial growth in susceptible organisms by interfering with bacterial protein synthesis
    • Binds to 30S and 50S ribosomal subunits, resulting in a defective bacterial cell membrane
    • Exhibit concentration-dependent bacterial killing (higher peak levels means more bacterial killing)
    • Has activity against many organisms, including susceptible Pseudomonas aeruginosa and Acinetobacter baumannii
  • May be given via the intravenous, intrathecal, ophthalmic or topical
  • Dosing is similar to tobramycin, while amikacin doses are typically larger than gentamicin or tobramycin doses on a mg/kg basis
  • Use of extended-interval IV doses is generally more favorable towards reducing toxicity and maximizing efficacy
    • Adjust IV gentamicin doses & frequency for kidney impairment
    • Monitoring drug levels may be indicated
    • Nephrotoxicity and ototoxicity are potential side effects of IV therapy
    • See below resources for more on dosing/monitoring

RESOURCES

  • Gentamicin IV Package Insert
  • Nebraska Stewardship Program PK Training Content
  • University Of Miami/ Jackson Memorial Hospital Dosing Guide
  • Basics Of Pharmacokinetics & Pharmacodynamics
  • PK-PD Compass
  • IDSA Practice Guidelines
  • Surgical Prophylaxis Guidelines

Free Antibiotic Cheat Sheet

Study Guide

  • Pharmacotherapy Study Guide
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