Cephalexin

KEY POINTS

• Cephalexin (Keflex) is a first-generation cephalosporin and beta-lactam antibiotic
• Works by binding to penicillin-binding-proteins and interfering with cell wall synthesis in susceptible bacteria
• Has activity versus methicillin-sensitive Staphylococcus aureus  (MSSA) and many Streptococcus species
• Has activity versus sensitive Proteus spp., E. coli, and Klebsiella spp. – “PEcK”
• Common use is skin and soft tissue infections
• Cefazolin (Ancef) is the injectable counterpart of oral cephalexin
• Frequency is usually 2-4 doses per day
  • Adjust doses for kidney dysfunction

RESOURCES

• Cephalexin Package Insert
• IDSA Practice Guidelines
• Surgical Prophylaxis Guidelines