KEY POINTS
- Doxycycline (Doryx) is a tetracycline antibiotic that inhibits bacterial protein synthesis through binding with the 30S ribosomal subunit
- Has activity versus many organisms, including community-acquired methicillin-resistant Staphylococcus aureus, Chlamydia trachomatis, Borrelia burgdorferi (the cause of lyme disease), Plasmodium sp. (the cause of malaria), and Treponema pallidum (the cause of syphilis), Bacillus anthracis (the cause of anthrax)
- Should not be used in persons less than 8 years of age, as it can cause tissue hyperpigmentation, tooth enamel hypoplasia or permanent tooth discoloration
- Pregnancy category D – should generally be avoided in pregnancy
- Beware phototoxicity, esophagitis and nausea
- Available oral and injectable
- There are a variety of oral formulations available
- 100mg twice daily is a common dose and frequency
- No adjustment needed in dose or frequency for kidney or liver dysfunction
RESOURCES
- Doxycycline Oral Package Insert
- Doxycycline Injection Package Insert
- 2015 CDC STD Guideline
- Surgical Prophylaxis Guidelines
- IDSA Lyme Disease Guideline
- IDSA Skin And Soft Tissue Infection Guideline
- IDSA Community Acquired Pneumonia Guideline
- IDSA MRSA Guideline
- CDC Malaria Page
- CDC Anthrax Page
- CDC Tularemia Page
- CDC Tickborne Rickettsial Disease Guideline