KEY POINTS
- Minocycline (Minocin) is a tetracycline antibiotic that inhibits bacterial protein synthesis through binding with the 30S ribosomal subunit
- Has activity versus many organisms, including community-acquired methicillin-resistant Staphylococcus aureus, Propionibacterium acnes, Stenotrophomonas maltophilia, Neisseria spp., and Mycobacterium spp.
- Should not be used in persons less than 8 years of age, as it can cause tissue hyperpigmentation, tooth enamel hypoplasia or permanent tooth discoloration
- Pregnancy category D – should generally be avoided in pregnancy
- Beware phototoxicity, esophagitis and nausea
- Available oral and injectable
- 100mg twice daily is a common dose and frequency for adults
- Generally do not exceed 200mg/day when CrCL < 80 mL/min
- No adjustments for hepatic dysfunction provided in package insert
RESOURCES
- Minocycline Injection Package Insert
- Minocycline Oral Capsule Package Insert
- Minocycline Extended-Release Package Insert (Solodyn)
- 2015 CDC STD Guideline
- Surgical Prophylaxis Guidelines
- IDSA Skin And Soft Tissue Infection Guideline
- IDSA Community Acquired Pneumonia Guideline
- IDSA Hospital Acquired Pneumonia & Ventilator-Associated Pneumonia Guideline
- IDSA MRSA Guideline
- Minocycline versus SMX/TMP monotherapy for Stenotrophomonas (JAC 2016)