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Eravacycline

 

Photo source: Tetraphase Pharmaceuticals, Inc.

KEY POINTS

  • Eravacycline (Xerava) is a synthetic tetracycline antibiotic that works via inhibition of the 30S ribosomal subunit
    • Less effected by tetracycline-specific resistance mechanisms (e.g., efflux pumps)
  • FDA-approved August 27, 2018 for complicated intra-abdominal infection (cIAI) in adults 18 years and older
  • Investigated for use with urinary tract infection, but outcomes were not favorable
  • Has activity versus Gram negative bacteria, including some multidrug-resistant isolates
    • In general, reserve for suspected or confirmed drug-resistant bacteria
    • Can have activity versus some carbapenem-resistant organisms and extended-spectrum beta-lactamase producing organisms
    • Has activity versus Acinetobacter baumannii, but acks activity versus Pseudomonas aeruginosa
  • Has activity versus some Gram positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE)
  • Has activity versus many anaerobic bacteria
  • Studied in injectable and oral formulations, but only injectable is currently FDA-approved
  • Dose is 1 mg/kg IV administered over 60 minutes, dosed every 12 hours
    • No dose adjustment needed for renal impairment
    • Adjust dose in severe hepatic impairment (Child Pugh C)
  • The most common adverse effects include GI effects (e.g., nausea & vomiting) and infusion site reactions
  • May cause tooth discoloration & enamel hypoplasia or inhibit bone growth during development (up to 8 years of age)

RESOURCES

  • Eravacycline Package Insert
  • Tetraphase FDA-Approval Announcement
  • Xerava.com
  • Eravacycline for the treatment of intra-abdominal infections [EOID 2014]
  • Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent [Drugs 2016]
  • Antibacterial Efficacy of Eravacycline In Vivo against Gram-Positive and Gram-Negative Organisms [AAC 2016]
  • Assessing the Efficacy and Safety of Eravacycline vs Ertapenem in Complicated Intra-abdominal Infections in the Investigating Gram-Negative Infections Treated With Eravacycline (IGNITE 1) Trial: A Randomized Clinical Trial [JAMA SURG 2017]

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