IDStewardship

  • Home
  • Articles
  • LEARN ANTIBIOTICS
  • Study Guide
  • Resources
  • Q&A
  • #ASPchat
  • Contributors
  • About

Top New ID/Stewardship Journal Articles Rundown: September 2019

In this article top new literature in the field of  infectious diseases and antimicrobial stewardship is identified. This monthly rundown can help you keep up with the latest and greatest material!



Written By: Bassam Ghanem, Pharm.D., MS, BCPS

Edited By: Timothy P. Gauthier, Pharm.D., BCPS-AQ ID


Last updated: 1 September 2019

In this monthly column two infectious diseases pharmacists who utilize Twitter to stay current with antimicrobial stewardship literature (@ABsteward [B.G.] & @IDstewardship [T.G.]) identify some of the top new hot off the press articles recently published.

The following are some of the new publications we found most interesting or noteworthy that were released in August of 2019. We get to learn each month from all of these amazing publications and hope you enjoy this list as much as we enjoy putting it together!

1. RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections | CID

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciz530/5546004

RESTORE-IMI 1 RCT concluded that IMI/REL had comparable efficacy but significantly less nephrotoxicity compared with colistin-based therapy for treatment of carbapenem-nonsusceptible gram-negative infections.

2. Daptomycin plus beta-lactam combination therapy for methicillin-resistant Staphylococcus aureus bloodstream infections: a retrospective, comparative cohort study | CID

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciz746/5548921

This multicenter retrospective study found that the addition of a beta-lactam to daptomycin was associated with improved clinical outcomes in patients with MRSA BSI.

3. Oral Fluoroquinolone or Trimethoprim-sulfamethoxazole vs. Beta-lactams as Step-Down Therapy for Enterobacteriaceae Bacteremia: Systematic Review and Meta-analysis | OFID

https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofz364/5550104

This systematic review concluded that there is a superiority of fluoroquinolones over oral beta-lactams in the IV to oral step-down treatment of GNR bacteremias , however there was insufficient data regarding outcomes after oral TMP-SMX in this setting.

4. Risk Factors and Outcomes Associated With Treatment of Asymptomatic Bacteriuria in Hospitalized Patients | JAMA Internal Medicine

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2748454

This large retrospective cohort study of hospitalized adults with ASB found that 82.7% received inappropriate antibiotic treatment. Antibiotic treatment was associated with a 37% longer duration of hospitalization without improved clinical outcomes.

5. Time-Series Analysis of Health Care Associated Infections in a New Hospital With All Private Rooms | JAMA Internal Medicine

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2747870

This time-series analysis found that the move to a new hospital with exclusively single-patient rooms appeared to be associated with a sustained decrease in the rates of new MRSA and VRE colonization and VRE infection without a reduction in CDI or MRSA infection.

6. Once-daily oral omadacycline versus twice-daily oral linezolid for acute bacterial skin and skin structure infections (OASIS-2): a phase 3, double-blind, multicentre, randomised, controlled, non-inferiority trial | Lancet ID

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(19)30275-0/fulltext

The OASIS 2 RCT concluded that once-daily oral omadacycline was non-inferior to twice-daily oral linezolid in adults with ABSSSI, plus was safe and well tolerated.



Additional New & Notable Publications

Contact precautions in single-bed or multiple-bed rooms for patients with extended-spectrum beta-lactamase-producing Enterobacteriaceae in Dutch hospitals: a cluster-randomised, crossover, non-inferiority study| Lancet ID

Effect of monthly high-dose vitamin D supplementation on acute respiratory infections in older adults: A randomized controlled trial | CID

Mechanical and oral antibiotic bowel preparation versus no bowel preparation for elective colectomy (MOBILE): a multicentre, randomised, parallel, single-blinded trial | Lancet

Safety and immunogenicity of the chlamydia vaccine candidate CTH522 adjuvanted with CAF01 liposomes or aluminium hydroxide: a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial | Lancet ID

Long-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis | Lancet Res Med

Feasibility of Core Antimicrobial Stewardship Interventions in Community Hospitals | JAMA Network Open

Efficacy of ceftazidime-avibactam in monotherapy or combination therapy against carbapenem resistant Gram-negative organisms: A meta-analysis | IJAA

Cefazolin Versus Anti-Staphylococcal Penicillins for the Treatment of Patients with Methicillin-Susceptible Staphylococcus aureus Infection: A Meta-Analysis with Trial Sequential Analysis | Infectious Diseases and Therapy

Molecular Epidemiology of Ceftriaxone-Nonsusceptible Enterobacterales Isolates in an Academic Medical Center in the United States | OFID

Antecedent Carbapenem Exposure as a Risk Factor for Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae (NCPCRE) and Carbapenemase-Producing Enterobacteriaceae (CPE) | AAC

Intravenous ceftriaxone at home versus intravenous flucloxacillin in hospital for children with cellulitis: a cost-effectiveness analysis | Lancet ID

Outcomes of an electronic medical record (EMR) driven intensive care unit (ICU)-antimicrobial stewardship (AMS) ward round: Assessing the Five Moments of Antimicrobial Prescribing | ICHE

Urinary antibacterial activity of fosfomycin and nitrofurantoin at registered dosages in healthy volunteers | IJAA

How Testing Drives Treatment in Asymptomatic Patients: Level of Pyuria Directly Predicts Probability of Antimicrobial Prescribing | CID

The Incidence and Diagnostic Yield of Repeat Urine Culture in Hospitalized Patients: An Opportunity for Diagnostic Stewardship | JCM

A multicenter study of the real-world use of ceftaroline versus vancomycin for acute bacterial skin and skin structure infections | AAC

The Impact of Penicillin Skin Testing on Aztreonam Stewardship and Cost Savings in Immunocompromised Cancer Patients | OFID

Impact of Procalcitonin Levels Combined with Active Intervention on Antimicrobial Stewardship in a Community Hospital | OFID

Sodium Glucose Cotransporter-2 Inhibitors and the Risk for Severe Urinary Tract Infections: A Population-Based Cohort Study | Annals of Internal Medicine

Telavancin in Hospital-Acquired and Ventilator-Associated Pneumonia (HAP/VAP) Caused by Staphylococcus aureus: Post Hoc Analysis of 2 Randomized, Controlled Trials | Infectious Diseases and Therapy

Effect of concomitant vancomycin and piperacillin-tazobactam on frequency of acute kidney injury in pediatric patients | AJHP

Impact of total body weight on rate of acute kidney injury in patients treated with piperacillin-tazobactam and vancomycin | AJHP

Activity of imipenem/relebactam against carbapenemase-producing Enterobacteriaceae with high colistin resistance | JAC

Ceftaroline-associated encephalopathy in patients with severe renal impairment | CID

Practice patterns of Infectious Diseases physicians in transitioning from intravenous to oral therapy in patients with bacteremia | OFID

Optimizing the Management of Uncomplicated Gram-Negative Bloodstream Infections in Children: Translating Evidence From Adults Into Pediatric Practice | JPIDS

Point-Counterpoint: Should serum Beta-D-glucan testing be used for the diagnosis of Pneumocystis jiroveci pneumonia? | JCM

Non-inferiority versus superiority trial design for new antibiotics in an era of high antimicrobial resistance: the case for post-marketing, adaptive randomised controlled trials | Lancet ID

Infectious complications of addiction: A call for a new subspecialty within infectious diseases | CID

Sustainable Discovery and Development of Antibiotics: Is a Nonprofit Approach the Future? | NEJM

Using social media to disseminate research in infection prevention, hospital epidemiology, and antimicrobial stewardship | ICHE

Emergence of Delafloxacin-Resistant Staphylococcus aureus in Brooklyn, NY | CID

Successful treatment with cefiderocol for compassionate use in a critically ill patient with XDR Acinetobacter baumannii and KPC-producing Klebsiella pneumoniae: a case report | JAC

Mechanisms of antimicrobial-induced nephrotoxicity in children | JAC

Epidemiology and Treatment of Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa Infections | CMR

How to start an antimicrobial stewardship programme in a hospital | CMI

Clostridioides difficile: diagnosis and treatments | BMJ

Treatment of Helicobacter pylori in Special Patient Populations | Pharmacotherapy

Updated good practice recommendations for outpatient parenteral antimicrobial therapy (OPAT) in adults and children in the UK | JAC AMR



 

Filed Under: Infectious Diseases & Antimicrobial Stewardship

LEARN ANTIBIOTICS

Paperback Book

Let’s Talk Micro

STEWARD PINS

Subscribe

Sign up for the monthly newsletter!

We will never spam you. We want you to like us. By clicking the Subscribe button, you accept the Terms of Service and Privacy Policy.

Categories

  • COVID-19
  • Healthcare At Large
  • Infectious Diseases & Antimicrobial Stewardship
  • Pharmacy News
  • Reality Check
  • Residency & Training
  • Facebook
  • Instagram
  • LinkedIn
  • Pinterest
  • Tumblr
  • Twitter
  • YouTube

Recent Posts

  • Five Things For Pharmacists To Know About The Treatment Of Mycobacterium Tuberculosis
  • Five Inconvenient Truths To Know About Infectious Diseases
  • Reality Versus Expectation: TikTok As An Educational Tool For Teaching Bugs & Drugs
  • Pharmacy Student Study Strategies To Maximizing Learning In 2025 And Beyond
  • 5 Things To Know About Interpreting MRSA Nares Swab Results

More Articles

5 Ways To Celebrate Antibiotic Awareness Week 2024

5 Ways To Celebrate Antibiotic Awareness Week 2024

5 Quick Tips For Pharmacy Residents Preparing Manuscripts

5 Quick Tips For Pharmacy Residents Preparing Manuscripts

5 Quick Things To Know About Drug Shortages

5 Quick Things To Know About Drug Shortages

Something Cool & Something Lame With 5 Antibiotics

Something Cool & Something Lame With 5 Antibiotics

Tags

antibiotic Antibiotics antimicrobial stewardship bcps beta-lactam cancer Chemotherapy Clinical Controversies clinical pharmacist clinical pharmacy community pharmacist Critical Care emergency medicine Emoji Game fellowship figure1 Hepatitis C hospital pharmacist hospital pharmacy Infectious Disease infectious diseases Lifestyle MRSA NAPLEX Natural Disaster oncology pharmacist one-on-one penicillin allergy PGY2 pharmacy fellowship Pharmacy Job pharmacy practice pharmacy residency pharmacy school pharmacy student Pharmacy technician PK-PD Compass Predatory Journals Rapid Diagnostic Testing residency social media student pharmacist study table transplant Zika

Recent

  • Five Things For Pharmacists To Know About The Treatment Of Mycobacterium Tuberculosis
  • Five Inconvenient Truths To Know About Infectious Diseases
  • Reality Versus Expectation: TikTok As An Educational Tool For Teaching Bugs & Drugs
  • Pharmacy Student Study Strategies To Maximizing Learning In 2025 And Beyond
  • 5 Things To Know About Interpreting MRSA Nares Swab Results

Search

Copyright 2016-2020 By Charlie Rose, LLC © · IDStewardship.com · Copyright · Privacy Policy · Terms · Contact