IDStewardship

  • Home
  • Articles
  • LEARN ANTIBIOTICS
  • Study Guide
  • Resources
  • Q&A
  • #ASPchat
  • Contributors
  • About

ICYMI: Top ID/Stewardship Journal Articles Just Released In July 2019

Here we identify infectious diseases & antimicrobial stewardship literature just released in July of 2019. We hope if you find this helpful, you will share it with others!



Written By: Bassam Ghanem, Pharm.D., MS, BCPS

Edited By: Timothy P. Gauthier, Pharm.D., BCPS-AQ ID


Last updated: 1 August 2019

In this monthly column two pharmacists who utilize Twitter to stay current with antimicrobial stewardship literature (@ABsteward [B.G.] & @IDstewardship [T.G.]) identify some of the top hot off the press articles recently published.

The following are some of the new publications we found most interesting or noteworthy that were released in July of 2019. We get to learn each month from all of these amazing publications and hope you enjoy this list as much as we enjoy putting it together!

1. Cefepime neurotoxicity: thresholds and risk factors. A Retrospective Cohort study | CMI

https://www.sciencedirect.com/science/article/pii/S1198743X19303799

This was the largest retrospective study to date for patients on cefepime who underwent therapeutic drug monitoring (TDM). It found that the overall incidence of neurotoxicity was 23.2% . The study concluded that TDM should be systematically performed especially for patients with lower renal function aiming at trough concentrations below 7.5 mg/L.

2. Excess Antibiotic Treatment Duration and Adverse Events in Patients Hospitalized With Pneumonia: A Multihospital Cohort Study | Annals of Internal Medicine

https://annals.org/aim/article-abstract/2737823/excess-antibiotic-treatment-duration-adverse-events-patients-hospitalized-pneumonia-multihospital

This large retrospective cohort study for patients with pneumonia found two thirds of patients received excess antibiotic therapy, with most antibiotics prescribed at discharge. Excess treatment was not associated with lower rates of any adverse outcomes, however each excess day associated with a 5% increase in the odds of antibiotic-associated adverse events.

3. When not to start antibiotics: avoiding antibiotic overuse in the intensive care unit | CMI

https://www.sciencedirect.com/science/article/abs/pii/S1198743X19303969

This narrative review addressed the safety and utility of a watchful waiting approach to antibiotic initiation with selected patients in the ICU. The review concluded that prospective trials that identify clinical situations wherein it is safe to delay or withhold antibiotic initiation in the ICU until the presence of an infection is proven are warranted.

4. Effect of oral oseltamivir on virological outcomes in low-risk adults with influenza: a randomized clinical trial | CID

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciz634/5539729

This randomized controlled trial found that oseltamivir decreased viral shedding in this low-risk adult population but did not significantly decrease the time to resolution of clinical symptoms.

5. Ceftazidime, carbapenems, or piperacillin-tazobactam as single definitive therapy for Pseudomonas aeruginosa bloodstream infection – a multi-site retrospective study | CID

https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciz668/5533273?redirectedFrom=fulltext

This multi-national retrospective study found no significant difference in mortality, clinical, and microbiological outcomes or adverse events between ceftazidime, carbapenems and piperacillin-tazobactam as definitive treatment of P. aeruginosa bacteremia.

6. Effectiveness of a Bundled Intervention Including Adjunctive Corticosteroids on Outcomes of Hospitalized Patients With Community-Acquired Pneumonia: A Stepped-Wedge Randomized Clinical Trial | JAMA Internal Medicine

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2737749

This stepped-wedge, cluster-randomized effectiveness trial found that a bundle of evidence-supported treatments (including adjunctive corticosteroids) failed to improve outcomes of patients with CAP and resulted in higher incidence of GI bleeding.



Additional New & Notable Publications

Global burden of latent multidrug-resistant tuberculosis: trends and estimates based on mathematical modeling | Lancet ID

Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread | Nature Microbiology

Neural-Tube Defects and Antiretroviral Treatment Regimens in Botswana | NEJM

What Antibiotic Exposures Are Required to Suppress the Emergence of Resistance for Gram-Negative Bacteria? A Systematic Review | Clinical Pharmacokinetics

Pharmacodynamics of daptomycin when prescribed in combination with other antibiotics for treatment of enterococcal bacteremia | IJAA

MSG-10: a Phase 2 study of oral ibrexafungerp (SCY-078) following initial echinocandin therapy in non-neutropenic patients with invasive candidiasis | JAC

Intravenous Vancomycin Therapeutic Drug Monitoring in Children: Evaluation of a Pharmacy-Driven Protocol and Collaborative Practice Agreement | JPIDS

Efficacy of colistin alone and in various combinations for the treatment of experimental osteomyelitis due to carbapenemase-producing Klebsiella pneumoniae | JAC

In vitro Activity of Imipenem-Relebactam Alone or in Combination with Amikacin or Colistin against Pseudomonas aeruginosa | AAC

Application of the Hartford Hospital Nomogram for Plazomicin Dosing Interval Selection in Patients with Complicated Urinary Tract Infection | AAC

Activity of imipenem-relebactam and comparator agents against genetically characterized isolates of carbapenem-resistant Enterobacteriaceae | AAC

Use of Antibiotics Without a Prescription in the U.S. Population: A Scoping Review | Annals of Internal Medicine

Graded Dalbavancin Challenge in a Patient with Severe Vancomycin Hypersensitivity Reaction | CID

Clinical impact of matrix-assisted laser desorption ionization time-of-flight mass spectrometry for the management of inpatient pneumonia without additional antimicrobial stewardship support | ICHE

Off-label use of Ceftaroline Fosamil: a systematic review | IJAA

Does oral vancomycin prophylaxis during systemic antibiotic exposure prevent Clostridioides difficile infection relapses? Still in search of an answer | ICHE

Teamwork and safety climate affect antimicrobial stewardship for asymptomatic bacteriuria | ICHE

A model for improving and assessing outpatient stewardship initiatives for acute respiratory infection | ICHE

Emotional, cognitive and social factors of antimicrobial prescribing: can antimicrobial stewardship intervention be effective without addressing psycho-social factors? | JAC

Influencing duration of antibiotic therapy: A behavior change analysis in long-term care | AJIC

Impact of triazole therapeutic drug monitoring availability and timing | AAC

Clinical outcomes following treatment of Enterobacter species pneumonia with piperacillin/tazobactam compared to cefepime or ertapenem | IJAA

Impact of Setting up an Endocarditis Team on the Management of Infective Endocarditis | OFID

Knowledge and Practices of Physicians and Nurses related to Urine Cultures in Catheterized Patients: An Assessment of Adherence to IDSA Guidelines | OFID

Outcomes of the PIRASOA programme, an antimicrobial stewardship programme implemented in hospitals of the public Health system of Andalusia, Spain: an ecological study of time-trend analysis | CMI

Penicillin as a Potential Agent for Dual Beta-lactam Therapy for Enterococcal Endocarditis | CID

Pharmacodynamics of plazomicin and a comparator aminoglycoside, amikacin, studied in an in vitro pharmacokinetic model of infection | IJAA

Current infection prevention and antibiotic stewardship program practices: A survey of the Society for Healthcare Epidemiology of America (SHEA) Research Network (SRN) | ICHE

Association between treatment duration and mortality or relapse in adult patients with Staphylococcus aureus bacteraemia: a retrospective cohort study | CMI

Comparison of Neutropenia Associated with Ceftaroline or Ceftriaxone in Patients Receiving at Least 7 Days of Therapy for Severe Infections | Pharmacotherapy

Early switching of antibiotic therapy from intravenous to oral using a combination of education, pocket-sized cards and switch advice: A practical intervention resulting in a reduction in length of hospital stay | IJAA

Standardizing Febrile Neutropenia Management: Antimicrobial Stewardship in the Hematologic Malignancy Population | JOP

Prevalence of Infective Endocarditis in Enterococcus faecalis Bacteremia | J Am Coll Cardio

Pharmacists’ Perceptions and Practice Changes Resulting from Emergence of the Vancomycin – Piperacillin/Tazobactam Nephrotoxicity Phenomenon | JAACP

Successful treatment with daptomycin and ceftaroline of MDR Staphylococcus aureus native valve endocarditis: a case report | JAC

Point-Counterpoint: Differences between the European Committee on Antimicrobial Susceptibility Testing and the Clinical Laboratory Standards Institute Recommendations for Reporting Antimicrobial Susceptibility Results | JCM

Significant Publications on Infectious Diseases Pharmacotherapy in 2018 | JPP

Pharmacokinetics-pharmacodynamics of Beta-lactamase inhibitors: are we missing the target? | Expert Review of Anti-Infective Therapy

Antibiotic Dosing for Critically Ill Adult Patients Receiving Intermittent Hemodialysis, Prolonged Intermittent Renal Replacement Therapy, and Continuous Renal Replacement Therapy: An Update | Annals of Pharmacotherapy

Antimicrobial Stewardship in Cancer Patients: The Time is Now | JNCCN

Duration of Antibiotic Therapy: Shorter Is Better | Annals of Internal Medicine


RECOMMENDED TO YOU


 

Filed Under: Infectious Diseases & Antimicrobial Stewardship

LEARN ANTIBIOTICS

Paperback Book

Let’s Talk Micro

STEWARD PINS

Subscribe

Sign up for the monthly newsletter!

We will never spam you. We want you to like us. By clicking the Subscribe button, you accept the Terms of Service and Privacy Policy.

Categories

  • COVID-19
  • Healthcare At Large
  • Infectious Diseases & Antimicrobial Stewardship
  • Pharmacy News
  • Reality Check
  • Residency & Training
  • Facebook
  • Instagram
  • LinkedIn
  • Pinterest
  • Tumblr
  • Twitter
  • YouTube

Recent Posts

  • Pharmacy Student Study Strategies To Maximizing Learning In 2025 And Beyond
  • 5 Things To Know About Interpreting MRSA Nares Swab Results
  • Five Tidbits From The Largest International Meeting Of Clinical Microbiologists & Infectious Diseases Specialists In 2025
  • Five Things For Pharmacists To Know About Measles in 2025
  • 5 Things You Need To Know About The Learn Antibiotics Book Of Games

More Articles

Something Cool & Something Lame With 5 Antibiotics

Something Cool & Something Lame With 5 Antibiotics

5 Neat Things From The World Of Antimicrobials

5 Neat Things From The World Of Antimicrobials

5 Instances Of Challenging Antibiotic Workflows

5 Instances Of Challenging Antibiotic Workflows

Advice For New Pharmacy Interns: A White Coat Ceremony Key Note Speech

Advice For New Pharmacy Interns: A White Coat Ceremony Key Note Speech

Tags

antibiotic Antibiotics antimicrobial stewardship bcps beta-lactam cancer Chemotherapy Clinical Controversies clinical pharmacist clinical pharmacy community pharmacist Critical Care emergency medicine Emoji Game fellowship figure1 Hepatitis C hospital pharmacist hospital pharmacy Infectious Disease infectious diseases Lifestyle MRSA NAPLEX Natural Disaster oncology pharmacist one-on-one penicillin allergy PGY2 pharmacy fellowship Pharmacy Job pharmacy practice pharmacy residency pharmacy school pharmacy student Pharmacy technician PK-PD Compass Predatory Journals Rapid Diagnostic Testing residency social media student pharmacist study table transplant Zika

Recent

  • Pharmacy Student Study Strategies To Maximizing Learning In 2025 And Beyond
  • 5 Things To Know About Interpreting MRSA Nares Swab Results
  • Five Tidbits From The Largest International Meeting Of Clinical Microbiologists & Infectious Diseases Specialists In 2025
  • Five Things For Pharmacists To Know About Measles in 2025
  • 5 Things You Need To Know About The Learn Antibiotics Book Of Games

Search

Copyright 2016-2020 By Charlie Rose, LLC © · IDStewardship.com · Copyright · Privacy Policy · Terms · Contact