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Top New ID/Stewardship Journal Articles: November 2019

In this article top new infectious diseases and antimicrobial stewardship journal articles are identified. Here are our picks to share with you for November 2019.



Written By: Bassam Ghanem, Pharm.D., MS, BCPS

Edited By: Timothy P. Gauthier, Pharm.D., BCPS-AQ ID


Last updated: 3 November 2019

In this monthly column two pharmacists with advanced training in infectious diseases and antimicrobial stewardship identify top new journal articles published in the peer-reviewed scientific literature. Many of these are identified, shared, and discussed via Twitter. The authors can be found on Twitter @ABsteward (B.G.) & @IDstewardship (T.G.).

It is very hard to keep up with all of the new publications that come out each month. We hope this can assist people in identifying new articles of interest. We additionally hope it can serve as a place to come back to if you find something of interest and need a link to it.

1. Oral vs Intravenous Antibiotics for Patients With Klebsiella pneumoniae Liver Abscess: A Randomized, Controlled Noninferiority Study | CID

https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciz881/5588353?redirectedFrom=fulltext

A-KLASS RCT concluded that early (< one week) step-down to oral antibiotics were non-inferior to intravenous antibiotics for the early treatment of Klebsiella pneumoniae liver abscess.

2. Antibiotic treatment for 6 days versus 12 days in patients with severe cellulitis: a multicentre randomised, double-blind, placebo-controlled, non-inferiority trial | CMI

https://www.sciencedirect.com/science/article/abs/pii/S1198743X1930504X

DANCE RCT concluded that antibiotic treatment for 12 days compared to 6 days in patients with severe cellulitis resulted in significantly more frequent relapses by day 90.

3. Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial | BMJ

https://www.bmj.com/content/367/bmj.l5654

AIM RCT concluded that three months of treatment with amoxicillin compared with placebo did not provide a clinically important benefit in patients with chronic low back pain and modic changes at the level of a previous disc herniation.

4. Penicillin V four times daily for five days versus three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci: randomised controlled, open label, non-inferiority study | BMJ

https://www.bmj.com/content/367/bmj.l5337

This RCT concluded that Penicillin V four times daily for five days was non-inferior in clinical outcome to penicillin V three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci.

5. Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to Beta-lactam Antibiotics | CID

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciz1000/5601183

The Study described the first reported GAS clinical isolates with elevated ampicillin, amoxicillin, and cefotaxime minimum inhibitory concentrations conferred by a pbp2x mutation, which could serve as a first step in development of resistance.



Additional New & Notable Publications

Extended-spectrum Beta-lactamase-producing Escherichia coli in human-derived and foodchain-derived samples from England, Wales, and Scotland: an epidemiological surveillance and typing study | Lancet ID

Levofloxacin prophylaxis in patients with newly diagnosed myeloma (TEAMM): a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial | Lancet Oncology

Early Infectious Disease Consultation Is Associated With Lower Mortality in Patients With Severe Sepsis or Septic Shock Who Complete the 3-Hour Sepsis Treatment Bundle | OFID

Relationship Status between Vancomycin Loading Dose and Treatment Failure in Patients with MRSA Bacteremia: It’s Complicated | Infectious Diseases and Therapy

Beta-Lactam pharmacodynamics in Gram-negative bloodstream infections in the critically ill | JAC

Bayesian clinical decision support-guided versus clinician-guided vancomycin dosing in attainment of targeted pharmacokinetic parameters in a paediatric population | JAC

Determining the utility of methicillin-resistant Staphylococcus aureus nares screening in antimicrobial stewardship | CID

A population pharmacokinetic model-guided evaluation of ceftolozane/tazobactam dosing in critically ill patients undergoing continuous venovenous hemodiafiltration | AAC

Sustainability of Handshake Stewardship: Extending a Hand Is Effective Years Later | CID

Laxative use does not preclude diagnosis or reduce disease severity in Clostridiodes difficile infection | CID

Clinical and economic impact of implementing OVIVA criteria on patients with bone and joint infections in OPAT | CID

The Overton window and a less dogmatic approach to antibiotics | CID

Putting the Dissemination and Implementation in Infectious Diseases | CID

Weight Gain Following Initiation of Antiretroviral Therapy: Risk Factors in Randomized Comparative Clinical Trials | CID

Reported Beta Lactam and Other Antibiotic Allergies in Solid Organ and Hematopoietic Cell Transplant Recipients | CID

The effectiveness of Contact Precautions on methicillin-resistant Staphylococcus aureus (MRSA) in long-term care across the United States | CID

Blood cultures versus respiratory cultures: Two different views of pneumonia | CID

Voriconazole efficacy against Candida glabrata and Candida krusei: preclinical data using a validated in vitro pharmacokinetic/pharmacodynamic model | JAC

Use of procalcitonin and a respiratory polymerase chain reaction panel to reduce antibiotic use via an EMR alert | CID

Pathogen-Negative Sepsis: An Opportunity for Antimicrobial Stewardship | OFID

Analysis of antibiotic use in a large network of emergency departments | AJHP

Anidulafungin as an alternative treatment for Pneumocystis jirovecii pneumonia in patients who could not tolerate Trimethoprim/sulfamethoxazole | IJAA

Antibiotic Prescribing Variability in a Large Urgent Care Network: A New Target for Outpatient Stewardship | CID

#WhyID: Crowdsourcing the Top Reasons to Choose Infectious Diseases in the Age of Twitter | OFID

Ensuring Sustainability of Needed Antibiotics: Aiming for the DART Board | Annals of IM

Sepsis hysteria: excess hype and unrealistic expectations | The Lancet

A Baker’s Dozen of Top Antimicrobial Stewardship Intervention Publications in 2018 | OFID

Research needs in antibiotic stewardship | ICHE

Carbapenem-sparing strategy: carbapenemase, treatment, and stewardship | Curr Opin Infect Dis

Aminoglycosides for infective endocarditis: time to say goodbye? | CMI

Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America | AJRCCM


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Filed Under: Infectious Diseases & Antimicrobial Stewardship

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