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ICYMI: Top ID/Stewardship Journal Articles Released In June 2019


Here we identify new infectious diseases & antimicrobial stewardship literature published in June 2019. We hope if you find this helpful, you will share it with others!



Written By: Bassam Ghanem, Pharm.D., MS, BCPS

Edited By: Timothy P. Gauthier, Pharm.D., BCPS-AQ ID


[Last updated: 1 July 2019]

In this monthly column two pharmacists who utilize Twitter to stay current with antimicrobial stewardship literature (@ABsteward [B.G.] & @IDstewardship [T.G.]) identify some of the top hot off the press articles recently published.

The following are some of the new publications we found most interesting or noteworthy that were released in June of 2019…

1. The Emperor’s New Clothes: Prospective Observational Evaluation of the Association between Initial Vancomycin Exposure and Failure Rates among Adult Hospitalized Patients with MRSA Bloodstream Infections (PROVIDE) | CID

https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciz460/5510260?redirectedFrom=fulltext

This prospective, multicenter observational study of hospitalized adults with MRSA bacteremia treated with vancomycin found that higher vancomycin exposures did not confer a lower treatment failure (TF) risk but were associated with more acute kidney injury (AKI). Patients with day-2 AUC < 515 experienced the best global outcomes (no TF and no AKI).

2. Solithromycin versus ceftriaxone plus azithromycin for the treatment of uncomplicated genital gonorrhoea (SOLITAIRE-U): a randomised phase 3 non-inferiority trial| LANCET

https://www.sciencedirect.com/science/article/abs/pii/S1473309919301161#!

The SOLITAIRE-U was a randomized controlled trial that found Solithromycin as a single 1000 mg dose did not reach the non-inferiority margin compared to ceftriaxone plus azithromycin for the treatment of gonorrhoea.

3. High-dose ceftriaxone for bacterial meningitis: optimization of administration scheme based on nomogram | AAC

https://aac.asm.org/content/early/2019/06/18/AAC.00634-19

This Population PK study in adult patients treated with high doses of ceftriaxone (above 4g or 75 mg/kg per day) for bacterial meningitis suggested that ceftriaxone administration scheme and posology should be adapted to eGFR and the weight.

4. Procalcitonin to distinguish viral from bacterial pneumonia: a systematic review and meta-analysis | CID

https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciz545/5523199?redirectedFrom=fulltext

This meta-analysis found that a procalcitonin level is unlikely to provide reliable evidence either to mandate administration of antibiotics or to enable withholding such treatment in patients with CAP.

5. Benzylpenicillin versus flucloxacillin for penicillin susceptible Staphylococcus aureus bloodstream infections from a large retrospective cohort study | IJAA

https://www.sciencedirect.com/science/article/pii/S0924857919301372

This large observational cohort study found a significant association between flucloxacillin use and all-cause mortality in PSSA bacteraemia when compared to benzylpenicillin.

6. Comparative effectiveness of exclusive exposure to nafcillin or oxacillin, cefazolin, piperacillin-tazobactam, and fluoroquinolones among a national cohort of Veterans with methicillin-susceptible Staphylococcus aureus bloodstream infection | OFID

https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofz270/5512320?searchresult=1

This national retrospective cohort study found that no difference in mortality was observed between nafcillin/ oxacillin and cefazolin or fluoroquinolones in hospitalized patients with MSSA bacteremia. However, higher mortality was observed with piperacillin/tazobactam as compared with nafcillin/ oxacillin/ cefazolin and similar when compared with fluoroquinolones.


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Additional New & Notable Publications

A Mortality Analysis of Letermovir Prophylaxis for Cytomegalovirus (CMV) in CMV-Seropositive Recipients of Allogeneic Hematopoietic-Cell Transplantation | CID

Efficacy of Ceftriaxone 1 g daily Versus 2 g daily for The Treatment of Community-Acquired Pneumonia: A Systematic Review with Meta-Analysis | Expert Review of Anti-infective Therapy

Cross-reactivity to cephalosporins and carbapenems in penicillin-allergic patients: Two systematic reviews and meta-analyses | JACI in Practice

Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis | LANCET

Omadacycline as a promising new agent for the treatment of infections with Mycobacterium abscessus | JAC

Comparing direct challenge to penicillin skin testing for the outpatient evaluation of penicillin allergy: A randomized, controlled trial | JACI in Practice

Clinical cure with ceftriaxone versus ceftaroline or ceftobiprole in the treatment of Staphylococcal pneumonia: a systematic review and meta-analysis | IJAA

Evaluation of Plazomicin, Tigecycline, and Meropenem Pharmacodynamic Exposure against Carbapenem-Resistant Enterobacteriaceae in Patients with Bloodstream Infection or Hospital-Acquired/Ventilator-Associated Pneumonia from the CARE Study | Infectious Diseases and therapy

Is direct oral amoxicillin challenge a viable approach for low-risk patients labelled with penicillin allergy? | JAC

Beta-Lactam and Sulfonamide Allergy Testing Should Be a Standard of Care in Immunocompromised Host | JACI in Practice

Prospective Observational Study Comparing Sepsis-2 and Sepsis-3 Definitions in Predicting Mortality in Critically Ill Patients | OFID

The Urine Culturing Cascade: Variation in Nursing Home Urine Culturing and Association with Antibiotic Use and C. difficile infection | CID

The Infected Diabetic Foot: Re-Evaluating the IDSA Diabetic Foot Infection Classification | CID

Long-acting lipoglycopeptides: lineless antibiotics for serious infections in persons who use drugs | OFID

Improving care for critically ill patients with community-acquired pneumonia | AJHP

Effect of antimicrobial stewardship with rapid MALDI-TOF identification and Vitek 2 antimicrobial susceptibility testing on hospitalization outcome | Diagnostic Microbiology

High dose trimethoprim-sulfamethoxazole and clindamycin for Staphylococcus aureus endocarditis | IJAA

Attributable mortality due to fluoroquinolone and extended-spectrum cephalosporin resistance in hospital-onset Escherichia coli and Klebsiella spp bacteremia: A matched cohort study in 129 Veterans Health Administration medical centers | ICHE

Improved mortality in Staphylococcus aureus bacteremia with the involvement of antimicrobial stewardship team and infectious disease consultation | ICHE

What Is the Evidence for Co-trimoxazole, Clindamycin, Doxycycline, and Minocycline in the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Pneumonia? | Annals of pharmacotherapy

Defining Target Vancomycin Trough Concentrations for Treating Staphylococcus aureus Infection in Infants Aged 0 to 90 Days | JAMA Ped

Personalized ertapenem prophylaxis for carriers of extended-spectrum beta-lactamase-producing Enterobacteriaceae undergoing colorectal surgery | CID

The Pitt Bacteremia Score Predicts Mortality in Non-Bacteremic Infections | CID

Parameters influencing the pharmacokinetics/pharmacodynamics of piperacillin/tazobactam in patients with febrile neutropenia and haematological malignancy: a prospective study | JAC

Bacterial brothers in arms: cooperation of Staphylococcus aureus and Pseudomonas aeruginosa during antimicrobial exposure | JAC

Candida albicans Augments Staphylococcus aureus Virulence by Engaging the Staphylococcal agr Quorum Sensing System | mBio

Syndrome-specific versus prospective audit and feedback interventions for reducing use of broad-spectrum antimicrobial agents | AJIC

Association between meeting core elements for inpatient antimicrobial stewardship and antibiotic utilization | ICHE

Which healthcare workers work with acute respiratory illness? Evidence from Canadian acute-care hospitals during 4 influenza seasons: 2010-2011 to 2013-2014 | ICHE

The impact of formulary restriction on the relative consumption of carbapenems in intensive care units at an academic medical center | ICHE

Benefits and Costs of Animal Virulence for Microbes | mBio

Sustainable Discovery and Development of Antibiotics: Is a Nonprofit Approach the Future? | NEJM

Inoculum effect of Beta-lactam antibiotics | JAC

A Laboratory Medicine Best Practices Systematic Review and Meta-analysis of Nucleic Acid Amplification Tests (NAATs) and Algorithms Including NAATs for the Diagnosis of Clostridioides (Clostridium) difficile in Adults | CMR

The role of fecal microbiota transplantation to reduce intestinal colonization with antibiotic-resistant organisms: the current landscape and future directions | OFID

Fecal microbiota transplantation for recurrent Clostridioides difficile infection | AJHP

Novel approaches to decrease inappropriate ambulatory antibiotic use | Expert Review of Anti-Infective Therapy

Hot Topics on Vertebral Osteomyelitis from the International Society of Antimicrobial Chemotherapy | IJAA

Preexposure Prophylaxis for the Prevention of HIV Infection: US Preventive Services Task Force Recommendation Statement | JAMA

Extensively Drug-Resistant Pseudomonas aeruginosa ST309 Harboring Tandem GES Enzymes: A Newly Emerging Threat in the United States | OFID

Treatment of tricuspid valve endocarditis with daptomycin and linezolid therapy | AJHP


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Filed Under: Infectious Diseases & Antimicrobial Stewardship

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