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ICYMI: Top ID/Stewardship Journal Articles Released In May 2019

This article provides a collection of new infectious diseases & antimicrobial stewardship literature published in May of 2019. Hot off the press, many of these have been released e-pub only. We put these noteworthy publications together here in one place for your convenience!



Written By: Bassam Ghanem, Pharm.D., MS, BCPS

Edited By: Timothy P. Gauthier, Pharm.D., BCPS-AQ ID


[Last updated: 2 June 2019]

In this monthly column two pharmacists who utilize Twitter to stay current with antimicrobial stewardship literature (@ABsteward [B.G.] & @IDstewardship [T.G.]) identify some of the top hot off the press articles recently published.

The following are some of the new publications we found most interesting or noteworthy that were released in May of 2019…

1. Gentamicin compared with ceftriaxone for the treatment of gonorrhoea (G-ToG): a randomised non-inferiority trial | Lancet

https://www.sciencedirect.com/science/article/pii/S0140673618328174

G-ToG RCT found that gentamicin did not reach the non-inferiority margin compared to ceftriaxone for the treatment of gonorrhoea, with both groups also given a single dose of azithromycin by mouth.

2. Risk for Tympanic Membrane Perforation after Quinolone Ear Drops for Acute Otitis Externa | CID

https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciz345/5482480?redirectedFrom=fulltext

This large cohort study found that the use of quinolone ear drops was associated with increased risk for tympanic membrane perforation compared with neomycin plus hydrocortisone.

3. Prophylactic antibiotics in the prevention of infection after operative vaginal delivery (ANODE): a multicentre randomised controlled trial | Lancet

ANODE trial showed that a single prophylactic dose of intravenous amoxicillin and clavulanic acid a median of 3 h after operative vaginal delivery halved maternal infection rate and reduce overall antibiotic use.

4. No Clinical Benefit to Treating Male Urinary Tract Infection Longer than Seven Days: An Outpatient Database Study | OFID

https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofz216/5486159

This multi-clinic study concluded that men with UTI without evidence of complicating conditions do not need to be treated for longer than 7 days.

5. Antibiotic treatment versus no treatment for asymptomatic bacteriuria in kidney transplant recipients: a multicenter randomized trial | OFID

https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofz243/5494787

This RCT found that antibiotic treatment of ASB did not prevent acute graft pyelonephritis in kidney transplant recipients and may increase antibiotic resistance.

6. Four versus six weeks of antibiotic therapy for osteoarticular infections after implant removal: a randomized trial | JAC

https://academic.oup.com/jac/advance-article-abstract/doi/10.1093/jac/dkz202/5491482?redirectedFrom=fulltext

This RCT found no statistically significant difference in the rates of clinical or microbiological remission between patients randomized to only 4 compared with 6 weeks of systemic antibiotic therapy following removal of an infected osteoarticular implant.

7. Beta-Lactam/Beta-Lactamase Inhibitor Therapy for Potential AmpC-Producing Organisms: A Systematic Review and Meta-Analysis | OFID

https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofz248/5498096?searchresult=1

This systematic review and meta-analysis found no significant difference in 30-day mortality between beta-lactam/beta-lactamase inhibitors and carbapenems in the treatment of bloodstream infections with AmpC-Producing pathogens.

8. Assessment of the Appropriateness of Antibiotic Prescriptions for Infection Prophylaxis Before Dental Procedures, 2011 to 2015 | JAMA

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2734798

This large cohort study found that more than 80% of antibiotic prophylaxis prescriptions before dental procedures are unnecessary.



Additional New & Notable Publications

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus | Nature Medicine

CRP-guided antibiotic treatment in acute exacerbations of COPD in hospital admissions | ERS

CAL02, a novel antitoxin liposomal agent, in severe pneumococcal pneumonia: a first-in-human, double-blind, placebo-controlled, randomised trial | Lancet ID

Safety and immunogenicity of a vaccine for extra-intestinal pathogenic Escherichia coli (ESTELLA): a phase 2 randomised controlled trial | Lancet Infect Dis 

Intraoperative Versus Extended Antibiotic Prophylaxis in Liver Transplant Surgery: A Randomized, Controlled Pilot Trial | Liver Transplantation

Short-course versus long-course antibiotics in prosthetic joint infections: a systematic review and meta-analysis of one randomized controlled trial plus nine observational studies | JAC

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis | JAMA

A Reappraisal of Linezolid Dosing in Renal Impairment to Improve Safety | AAC

Greater Weight Gain in Treatment Naive Persons Starting Dolutegravir-Based Antiretroviral Therapy | CID

Clinical impact of rapid species identification from positive blood cultures with same-day phenotypic antimicrobial susceptibility testing on the management and outcome of bloodstream infections | CID

Antibiotic Prescribing and Respiratory Viral Testing for Acute Upper Respiratory Infections Among Adult Patients at an Ambulatory Cancer Center | CID

The Likelihood of Developing a Carbapenem-Resistant Enterobacteriaceae Infection during the Hospital Stay | AAC

Total duration of antimicrobial therapy resulting from inpatient hospitalization | ICHE

Trends in and predictors of carbapenem consumption across North American hospitals: results from a multi-center survey by the MAD-ID Research Network | AAC

Treatment duration and associated outcomes for skin and soft tissue infections in patients with obesity or heart failure | OFID

Readiness to implement vancomycin monitoring based on area under the concentration–time curve: A cross-sectional survey of a national health consortium | AJHP

Antibiotic use and outcomes after implementation of the Drug Resistance in Pneumonia (DRIP) score in emergency department patients with community-onset pneumonia | CHEST

Comparison of ceftazidime-avibactam and Ceftolozane-Tazobactam in vitro activities when tested against gram-negative Bacteria isolated from patients hospitalized with pneumonia in United States medical centers (2017 to 2018) | Diagnostic Microbiology

Non-intravenous carbapenem-sparing antibiotics for the definitive treatment of bacteremia due to Enterobacteriaceae-producing ESBL or AmpC beta-lactamase. A propensity score study | IJAA

Periprosthetic joint infections as a consequence of bacteremia | OFID

Hourly Effect of Pretreatment With IV Antibiotics on Blood Culture Positivity Rate in Emergency Department Patients | OFID

Dose, Timing, and Type of Infant Antibiotic Use and the Risk of Childhood Asthma | CID

Evaluation of early clinical failure criteria for Gram-negative bloodstream infections | CMI

Dalbavancin Use in Vulnerable Patients Receiving Outpatient Parenteral Antibiotic Therapy for Invasive Gram-Positive Infections | Infectious Diseases and Therapy

Twenty-four hour pharmacokinetic relationships for intravenous vancomycin and novel urinary biomarkers of acute kidney injury in a rat model | JAC

Two cases of severe neutropenia in patients on low-dose methotrexate and ceftriaxone | AJHP

Pharmacy Driven Assessment of Appropriate Antibiotic Selection in Patients with Reported Beta-Lactam Allergy | JACCP

Transition from intravenous to oral antimicrobial therapy in patients with uncomplicated and complicated bloodstream infections | CMI

Don’t Get Wound Up: Revised Fluoroquinolone Breakpoints for Enterobacteriaceae and Pseudomonas aeruginosa | JCM

Antibiotic stewardship in the intensive care unit: Challenges and opportunities | ICHE

Understanding and Addressing CLSI Breakpoint Revisions: a Primer for Clinical Laboratories | JCM

Clinical Pharmacokinetics, Pharmacodynamics, Safety and Efficacy of Liposomal Amphotericin B | CID

Antibiotics in the Pipeline for Treatment of Infections due to Gram-Negative Organisms | Current Treatment Options in Infectious Diseases

The new, new daptomycin breakpoint for Enterococcus spp. | JCM

Echinocandins for the treatment of invasive aspergillosis: from laboratory to bedside | AAC

Eravacycline: The Tetracyclines Strike Back | Annals of pharmacotherapy

How scientists and physicians use Twitter during a medical congress | CMI

Self-reported beta-lactam intolerance: not a class effect, dangerous to patients, and rarely allergy | Expert Rev Anti Infect Ther

Beta-lactam Allergy Review: Implications for Antimicrobial Stewardship Programs | Current Treatment Options in Infectious Diseases

Antibiotic treatment versus no treatment for asymptomatic bacteriuria in kidney transplant recipients: a multicenter randomized trial | OFID


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Filed Under: Infectious Diseases & Antimicrobial Stewardship

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