This article identifies some of the hot new publications in the infectious diseases and antimicrobial stewardship literature released in January 2019. This list is derived from content circulating on Twitter.
Written By: Bassam Ghanem, Pharm.D., MS, BCPS
Edited By: Timothy P. Gauthier, Pharm.D., BCPS-AQ ID
[Last updated: 4 February 2019]
In this monthly column two pharmacists who utilize Twitter to stay current on literature (@ABsteward [B.G.] & @IDstewardship [T.G.]) identify some of the hot new articles in the fields of antimicrobial stewardship and infectious diseases.
The following are some of the new publications we found most interesting or noteworthy in January of 2019…
1. Oral versus intravenous antibiotics for bone and joint infection | NEJM
OVIVA is a randomized controlled trial that showed oral antibiotic therapy was noninferior to IV when used during the first 6 weeks for complex orthopedic infection. While an important study, there was notable heterogeneity within the study population.
2. Impact of beta-lactam and daptomycin combination therapy on clinical outcomes in methicillin-susceptible Staphylococcus aureus bacteremia: a propensity score-matched analysis | CID
This retrospective cohort study found that a beta-lactam in combination with daptomycin failed to reduce mortality rates in patients with MSSA bacteremia as compared to beta-lactam monotherapy.
3. Extended infusion of beta-lactams for bloodstream infection in patients with liver cirrhosis: an observational multicenter study | CID
This prospective, multicenter study showed that continuous/extended infusion of beta-lactams in cirrhotic patients with BSI may improve outcomes and facilitate earlier discharge.
4. Association of 30-day mortality with oral step-down versus continued intravenous therapy in patients hospitalized with Enterobacteriaceae bacteremia | JAMA
This retrospective multicenter cohort study showed that 30-day mortality was not different among hospitalized patients who received oral step-down within the first 5 days versus continued parenteral antibiotics therapy for the treatment Enterobacteriaceae bacteremia.
5. Association of Antibiotic Treatment With Outcomes in Patients Hospitalized for an Asthma Exacerbation Treated With Systemic Corticosteroids | JAMA
This large cohort study for patients hospitalized for an asthma exacerbation treated with corticosteroids showed that 44% of patients received antibiotics during the first 2 days of hospitalization. Patients treated with antibiotics had a significantly longer hospital stay, similar rate of treatment failure, and higher risk of antibiotic-related diarrhea.
Additional New & Notable Publications
Cadazolid for the treatment of Clostridium difficile infection: results of two double-blind, placebo-controlled, non-inferiority, randomised phase 3 trials | Lancet Infect Dis
A five-day course of oral antibiotics followed by faecal transplantation to eradicate carriage of multidrug-resistant Enterobacteriaceae: A Randomized Clinical Trial | CMI
Dolutegravir monotherapy versus dolutegravir/abacavir/lamivudine for virologically suppressed people living with chronic HIV infection: the randomized non-inferiorityu MONCAY trial | CID
Appropriateness of outpatient antibiotic prescribing among privately insured US patients: ICD-10-CM based cross sectional study | BMJ
Outpatient Parenteral Antibiotic Treatment (OPAT) for Infective Endocarditis: a Prospective Cohort Study From the GAMES Cohort | CID
Evaluation and Management of Penicillin Allergy: A Review | JAMA
A practical guide for pharmacists to successfully implement penicillin allergy skin testing | AJHP
Effectiveness of interventions involving pharmacists on antibiotic prescribing by general practitioners: a systematic review and meta-analysis | JAC
A Combination Antibiogram Evaluation for Pseudomonas aeruginosa in Respiratory and Blood Sources from ICU and Non-ICU Settings in US Hospitals | AAC
Fluoroquinolone-based versus beta lactam-based regimens for complicated intra-abdominal infections: a meta-analysis of randomized controlled trials | IJAA
Ceftaroline Fosamil for the Treatment of Gram-Positive Endocarditis: CAPTURE Study Experience | IJAA
Late-Career Physicians Prescribe Longer Courses of Antibiotics | CID
Pharmacist-led antimicrobial stewardship program in an urgent care setting | AJHP
Developing an antimicrobial stewardship program across a rural health system: The Avera Health experience | AJHP
Short Course Antibiotic Therapy – Replacing Constantine Units with “Shorter Is Better” | CID
Systematic Review of the Clinical Utility of Methicillin-Resistant Staphylococcus aureus (MRSA) Nasal Screening for MRSA Pneumonia | Annals of Pharmacotherapy
Understanding the components, calculation and impact of monthly and seasonal variation of the SAAR: Illustrative Data | AAC
How to: Implement procalcitonin testing in my practice | CMI
Procalcitonin to guide antibiotic decision making | Current Opinion in Infectious Diseases
Intravenous fosfomycin for the treatment of multidrug resistant pathogens: what is the evidence on dosing regimens? | Expert Review of Anti-infective Therapy
Aspiration pneumonia and pneumonitis a spectrum of infectious/noninfectious diseases affecting the lung | Current Opinion in Infectious Diseases
Early discontinuation of antibiotics for febrile neutropenia versus continuation until neutropenia resolution in people with cancer | Cochrane library
Clinical Practice Variation Among Adult Infectious Diseases Physicians in the Management of Staphylococcus aureus Bacteremia | CID
Association of Prescribed Opioids With Increased Risk of Community-Acquired Pneumonia Among Patients With and Without HIV | JAMA
Cardiac events after macrolides or fluoroquinolones in patients hospitalized for community-acquired pneumonia: post-hoc analysis of a cluster-randomized trial | BMC Infectious Diseases
Penicillin skin testing in methicillin-sensitive Staphylococcus aureus bacteremia: A cost-effectiveness analysis | plos one
Are standard dosing regimens of ceftriaxone adapted for critically ill patients with augmented creatinine clearance? A prospective observational study | AAC
Investigating the cultural and contextual determinants of antimicrobial stewardship programmes across low-, middle- and high-income countries – a qualitative study | plos one
Phage Therapy in the Postantibiotic Era | CMR
Adjuvant beta-lactam therapy combined with vancomycin for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia: Does beta-lactam class matter? | AAC
Moving beyond unsolicited consultation: additional impact of a structured intervention on mortality in Staphylococcus aureus bacteraemia | JAC
Partial Oral Therapy for Osteomyelitis and Endocarditis – Is It Time? | NEJM
Two-Site Evaluation of the Colistin Broth Disk Elution Test To Determine Colistin In Vitro Activity against Gram-Negative Bacilli | JCM
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