This article identifies some of the hot new publications in the infectious diseases and antimicrobial stewardship literature released in December 2018. This list is derived from content circulating on Twitter.
Written By: Bassam Ghanem, Pharm.D., MS, BCPS
Edited By: Timothy P. Gauthier, Pharm.D., BCPS-AQ ID
[Last updated: 1 January 2019]
In this monthly column two pharmacists that utilize Twitter to stay current on literature (@ABsteward [B.G.] & @IDstewardship [T.G.]) identify some of the hot new articles in the fields of antimicrobial stewardship & infectious diseases.
The following are some of the new publications we found most interesting or noteworthy in December of 2018…
1. Seven versus fourteen Days of Antibiotic Therapy for uncomplicated Gram-negative Bacteremia: a Non-inferiority Randomized Controlled Trial | CID
This RCT showed that an antibiotic course of 7 days was non-inferior to 14 days in patients with Gram-negative bacteremia achieving clinical stability before day 7.
2. Dalbavancin for the Treatment of Osteomyelitis in Adult Patients: A Randomized Clinical Trial of Efficacy and Safety | OFID
This RCT showed that 2-doses regimen of weekly dalbavancin can be effective and well-tolerated for the treatment of osteomyelitis in adults.
3. IGNITE4: Results of a Phase 3, Randomized, Multicenter, Prospective Trial of Eravacycline vs. Meropenem in the Treatment of Complicated Intra-Abdominal Infections | CID
This RCT showed that eravacycline was noninferior to meropenem in adult patients with cIAI, including infections caused by drug-resistant pathogens.
4. Duration of Exposure to Antipseudomonal Beta-lactam Antibiotics in the Critically Ill and Development of New Resistance | Pharmacotherapy
This retrospective study showed that each additional day of exposure to antipseudomonal beta-lactam antibiotics in critically ill patients increases the risk for the development of new antibiotic resistance.
5. Impact of de-escalation on prognosis of patients with bacteraemia due to Enterobacteriaceae: a post-hoc analysis from a multicenter prospective cohort | CID
A post-hoc analysis from a multicenter prospective cohort study showed that de-escalation in patients with monomicrobial bacteraemia due to Enterobacteriaceae was not associated with a detrimental impact on clinical outcome.
6. Impact of a Prescriber-driven Antibiotic Time-out on Antibiotic Use in Hospitalized Patients | CID
This multicenter quasi-experimental study of a provider-driven antibiotic time-out showed that single time-outs without input from antibiotic stewardship teams are insufficient to optimize antibiotic prescribing in hospitalized Patients.
ADDITIONAL NEW & NOTABLE PUBLICATIONS
Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenza | CID
Pharmacokinetics and Pharmacodynamics of Beta-lactamase Inhibitors | Pharmacotherapy
Omadacycline: A New Tetracycline Antibiotic | Annals of pharmacotherapy
Plazomicin, a Next-Generation Aminoglycoside | Pharmacotherapy
Prevention of Clostridium difficile Infection in Critically Ill Adult | Pharmacotherapy
Common Bacterial and Viral Infections: Review of Management in the Pregnant Patient | Annals of pharmacotherapy
Fidaxomicin versus oral vancomycin for severe Clostridium difficile infection: a retrospective cohort study | CMI
Procalcitonin-guided antibiotic therapy reduces antibiotic use for lower respiratory tract infections in a US medical center: results of a clinical trial | OFID
A Cluster of Cefepime-induced Neutropenia during Outpatient Parenteral Antimicrobial Therapy | CID
Carbapenem versus Cefepime or Piperacillin-Tazobactam for the Empiric Treatment of Extended Spectrum β-lactamase Producing Escherichia coli Bacteremia in Patients with Hematologic Malignancy | AAC
Antimicrobial stewardship programs in long-term care settings: a meta-analysis and systematic review | JASG
Cefazolin as surgical antimicrobial prophylaxis in hysterectomy: A systematic review and meta-analysis of randomized controlled trials | ICHE
Tolerability of long-term fluconazole therapy | JAC
Empiric Antibiotic Treatment Thresholds for Serious Bacterial Infections: A Scenario-Based Survey Study | CID
No Impact of Probiotics to Reduce Clostridium difficile Infection in Hospitalized Patients: A Real-world Experience | OFID
The Role of Ertapenem for the Treatment of Complicated Intra-abdominal Infections with a Positive Culture for Enterococcus faecalis | OFID
Treatment of chronic osteomyelitis with multi-dose oritavancin: a case series and literature review | IJAA
The Hypothetical Impact of Accelerate Pheno (ACC) on Time to Effective Therapy and Time to Definitive Therapy for bloodstream infections due to drug-resistant Gram-negative bacilli | AAC
Predictors of time to effective and time to optimal antimicrobial therapy in patients with positive blood cultures identified via molecular rapid diagnostic testing | OFID
Association of Screening and Treatment for Preoperative Asymptomatic Bacteriuria With Postoperative Outcomes Among US Veterans | JAMA
Pharmacokinetic evaluation of linezolid administered intravenously in obese patients with pneumonia | JAC
Rethinking How Antibiotics Are Prescribed Incorporating the 4 Moments of Antibiotic Decision Making Into Clinical Practice | JAMA
It is time to define antimicrobial never events | ICHE
All aboard!: Involvement of medical and pharmacy trainees in antimicrobial stewardship | ICHE
Supervised machine learning for the prediction of infection on admission to hospital: a prospective observational cohort study | JAC
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