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In Case You Missed It: Hot ID/stewardship Journal Articles Trending On Twitter From November 2018

This article identifies some of the hot new publications in the infectious diseases and antimicrobial stewardship literature from November 2018. They are derived from content circulating on Twitter.



Written By: Bassam Ghanem, Pharm.D., MS, BCPS

Edited By: Timothy P. Gauthier, Pharm.D., BCPS-AQ ID


[Last updated: 10 December 2018]

In this monthly column two pharmacists that are twitter enthusiasts (@ABsteward [B.G.] & @IDstewardship [T.P.G.]) identify some of the hot new articles in the fields of antimicrobial stewardship & infectious diseases.

The following are some of the new publications we found most interesting or noteworthy in November of 2018…

1. Substitution of ethambutol with linezolid during the intensive phase of treatment of pulmonary tuberculosis: a prospective, multicentre, randomised, open-label, phase 2 trial | Lancet Infect Dis.

https://www.sciencedirect.com/science/article/pii/S1473309918304808

This randomized controlled trial showed that linezolid for 2 weeks or 4 weeks instead of ethambutol during the intensive phase of treatment of pulmonary tuberculosis did not increase the proportion of sputum culture conversion at 8 weeks in the modified intention-to-treat analyses.

2. Sequential intravenous-to-oral outpatient antibiotic therapy for MRSA bacteraemia: one step closer | JAC.

https://academic.oup.com/jac/advance-article-abstract/doi/10.1093/jac/dky452/5168500?redirectedFrom=fulltext

This retrospective cohort study found that selected patients with MRSA bloodstream infection may have at least equivalent clinical outcomes with oral outpatient antibiotic therapy versus outpatient parenteral antibiotic therapy.

3. Cefazolin versus anti-staphylococcal penicillins for the treatment of methicillin-susceptible Staphylococcus aureus bloodstream infections in acutely-ill adult patients: results of a systematic review and meta-analysis | IJAA

https://www.sciencedirect.com/science/article/pii/S0924857918303388?via%3Dihub

This systematic literature review and meta-analysis found that Cefazolin was associated with improved clinical outcomes and moderately lower risk of treatment-associated adverse drug reactions compared to anti-staphylococcal penicillins in the treatment of MSSA bloodstream infections.

4. Long-Term Effects of Phased Implementation of Antimicrobial Stewardship in Academic ICUs| Critical Care Medicine.

https://journals.lww.com/ccmjournal/pages/articleviewer.aspx?year=9000&issue=00000&article=96090&type=Abstract

This phased, multisite cohort study of a quality improvement initiative implemented in four academic ICUs in Toronto found that antimicrobial stewardship in ICUs with coaching plus audit and feedback is associated with sustained improvements in antimicrobial consumption and cost.

5. Inadequate perioperative prophylaxis and postsurgical complications after graft implantation are important risk factors for subsequent vascular graft infections – prospective results from the VASGRA Cohort Study | CID

https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciy956/5161086

This prospective Cohort study found that long procedure time, inadequate perioperative prophylaxis, especially among patients with an established antibiotic treatment, postoperative complications contribute to the risk of developing vascular graft infections.

6. The Differences in Antibiotic Decision-making Between Acute Surgical and Acute Medical Teams: An Ethnographic Study of Culture and Team Dynamics | CID

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciy844/5174860

This is an ethnographic observational study describing antibiotic decision making, culture, and team dynamics differences between acute surgical & medical teams.



ADDITIONAL NEW & NOTABLE PUBLICATIONS

Advances in optimizing the prescription of antibiotics in outpatient settings |BMJ

Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis | Lancet Infect Dis

Reappraisal of Contemporary Pharmacokinetic and Pharmacodynamic Principles for Informing Aminoglycoside Dosing | Pharmacotherapy

A recipe for antimicrobial stewardship success: Using intervention mapping to develop a program to reduce antibiotic overuse in long-term care | ICHE

Blood Culture Turnaround Time in U.S. Acute Care Hospitals and Implications for Laboratory Process Optimization | JCM

Intrapulmonary pharmacokinetics of antibiotics used to treat nosocomial pneumonia caused by gram-negative bacilli: a systematic review | IJAA

Developing a Risk Prediction Model for 30-Day Unplanned Hospitalisation in Patients Receiving Outpatient Parenteral Antimicrobial Therapy | CMI

Can corticosteroids reduce the mortality of patients with severe sepsis? A systematic review and meta-analysis | AJEM

A Prospective Multicenter Clinical Observational Study on Vancomycin Efficiency and Safety With Therapeutic Drug Monitoring | CID

2018 IDSA Clinical Practice Guideline for the Management of Outpatient Parenteral Antimicrobial Therapy | CID

Intravenous catheter-related adverse events exceed drug-related adverse events in outpatient parenteral antimicrobial therapy | JAC

Re-estimating annual deaths due to multidrug-resistant organism infections | ICHE

The quality of studies evaluating antimicrobial stewardship interventions: a systematic review | CMI

The Relative Impact of Community and Hospital Antibiotic Use on the Selection of Extended-Spectrum Beta-lactamase-Producing Escherichia coli | CID

The safety and efficacy of an oral penicillin challenge program in cancer patients – A pilot multicentre study | OFID

Nephrotoxicity prevalence in patients treated with polymyxins: A systematic review with meta-analysis of observational studies | Diagnostic Microbiology and Infectious Disease

Treatment outcomes of colistin and carbapenem-resistant Acinetobacter baumannii infections: an exploratory subgroup analysis of a randomized clinical trial | CID

Multidisciplinary authorship among Infectious Diseases Society of America clinical practice guidelines: Examining the contributions of infectious diseases pharmacists | OFID

Impact of tiered interventions to decrease routine urine cultures in asymptomatic patients undergoing arthroplasty | ICHE

Oral Vancomycin for Secondary Prophylaxis of Clostridium difficile Infection | Annals of Pharmacotherapy

A prospective study of transmission of Multidrug-Resistant Organisms (MDROs) between environmental sites and hospitalized patients—the TransFER study | ICHE



 

Filed Under: Infectious Diseases & Antimicrobial Stewardship

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