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ICYMI: Infectious Diseases & Antimicrobial Stewardship Journal Articles Hot Off The Press In February 2019

This article identifies new infectious diseases & antimicrobial stewardship literature released in February 2019. Hot off the press and put together here in one place!



Written By: Bassam Ghanem, Pharm.D., MS, BCPS

Edited By: Timothy P. Gauthier, Pharm.D., BCPS-AQ ID


[Last updated: 4 March 2019]

In this monthly column two pharmacists who utilize Twitter to stay current with antimicrobial stewardship literature (@ABsteward [B.G.] & @IDstewardship [T.G.]) identify some of the top hot off the press articles recently published.

The following are some of the new publications we found most interesting or noteworthy in February of 2019…

1. Efficacy and Safety of IV-to-Oral Lefamulin, a Pleuromutilin Antibiotic, for Treatment of Community-Acquired Bacterial Pneumonia: The Phase 3 LEAP 1 Trial | CID

https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciz090/5306243?redirectedFrom=fulltext

  • The LEAP 1 RCT showed that lefamulin was non-inferior to moxifloxacin for the primary efficacy endpoints and was generally safe and well tolerated.

2. Omadacycline for Community-Acquired Bacterial Pneumonia | NEJM

https://www.nejm.org/doi/full/10.1056/NEJMoa1800201?query=featured_home

  • The OPTIC RTC showed that omadacycline was non-inferior to moxifloxacin for the treatment of community-acquired bacterial pneumonia in adults.

3. Omadacycline for Acute Bacterial Skin and Skin-Structure Infections | NEJM

https://www.nejm.org/doi/full/10.1056/NEJMoa1800170?query=featured_home

  • The OASIS-1 RCT showed that Omadacycline was non-inferior to linezolid for the treatment of acute bacterial skin and skin-structure infections and had a similar safety profile.

4. Once-Daily Plazomicin for Complicated Urinary Tract Infections | NEJM

https://www.nejm.org/doi/full/10.1056/NEJMoa1801467

  • The EPIC RCT showed that once-daily plazomicin was non-inferior to meropenem for the treatment of complicated UTIs and acute pyelonephritis caused by Enterobacteriaceae, including multidrug-resistant strains.

5. Conversion from Vancomycin Trough Concentration-Guided Dosing to Area Under the Curve-Guided Dosing Using Two Sample Measurements in Adults: Implementation at an Academic Medical Center | Pharmacotherapy

https://doi.org/10.1002/phar.2234

  • In this prospective observational study, AUC-based dosing using two-point sampling improved therapeutic target attainment compared with a trough concentration-based dosing strategy.

6. Decolonization to Reduce Postdischarge Infection Risk among MRSA Carriers | NEJM

https://www.nejm.org/doi/full/10.1056/NEJMoa1716771

  • The CLEAR RCT showed post-discharge MRSA decolonization with chlorhexidine and mupirocin for 5 days twice per month for 6 months led to a 30% lower risk of MRSA infection than education alone.

7. Antibiotic treatment duration for bacteremia due to Enterobacteriaceae: A systematic review and meta-analysis | AAC

https://aac.asm.org/content/early/2019/02/21/AAC.02495-18

  • In this systematic review, short (<10 days) and long-course antibiotic (>10 days) treatment did not differ significantly in terms of clinical outcomes in patients with bacteremia due to Enterobacteriaceae.


Additional New & Notable Publications

Twitter to engage, educate, and advocate for global antibiotic stewardship and antimicrobial resistance | Lancet Infect Dis

Rapid detection of methicillin-resistant Staphylococcus aureus in bronchoalveolar lavage: A pilot randomized controlled trial | CHEST

Incidence of Acute Kidney Injury in Critically Ill Patients Receiving Vancomycin with Concomitant Piperacillin/Tazobactam, Cefepime, or Meropenem | AAC

Effectiveness and safety of electronically delivered prescribing feedback and decision support on antibiotic use for respiratory illness in primary care: REDUCE cluster randomised trial | BMJ

Vancomycin Area under the Curve and Acute Kidney Injury: A Meta-analysis | CID

Procalcitonin-Guided Antibiotic Discontinuation and Mortality in Critically Ill Adults: A Systematic Review and Meta-Analysis | CHEST

Defining optimal dosing of ciprofloxacin in patients with septic shock | JAC

Clinical and Economic Outcomes of Penicillin Skin Testing as an Antimicrobial Stewardship Initiative in a Community Health System | OFID

The Impact of Concomitant Empiric Cefepime on Patient Outcomes of Methicillin-Resistant Staphylococcus aureus Bloodstream Infections treated with Vancomycin | OFID

Use of microbiology tests in the era of increasing AMR rates– a multicentre hospital cohort study | ARIC

Value of hospital antimicrobial stewardship programs [ASPs]: a systematic review | ARIC

Augmented Renal Clearance | Pharmacotherapy

Advancing Infectious Diseases Diagnostic Testing and Applications to Antimicrobial Therapy in the ICU | Journal of Pharmacy Practice

Healthcare-associated pneumonia: Any reasons to still utilize this label in 2019? | CMI

Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical | Nature reviews Microbiology

Antimicrobial treatment challenges in the era of Carbapenem resistance |Diagnostic Microbiology and Infectious Disease

International Consensus Guidelines for the Optimal Use of the Polymyxins Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti‐infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP) | Pharmacotherapy

Recommended Adult Immunization Schedule, United States, 2019 | Annals of Internal medicine

Urinary Tract Infections in Solid Organ Transplant Recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice | Clin Transplant

Prevalence, Underlying Causes, and Preventability of Sepsis-Associated Mortality in US Acute Care Hospitals | JAMA

Perceptions and Practices for Beta-Lactam Antibiotic Dosing, Administration, and Monitoring in Critically Ill Patients: Current Views and Use Among Critical Care and Infectious Diseases Pharmacists | JACCP

Successful implementation of an antibiotic stewardship program in an academic dental practice| OFID

The Infectious Diseases Society of America’s 10 × ’20 Initiative (Ten New Systemic Antibacterial Agents FDA-approved by 2020): Is 20 × ’20 a Possibility? | CID

Implementation of a pharmacist-led penicillin allergy de-labelling service in a public hospital | JAC

Vancomycin Versus Metronidazole for Nonsevere Clostridioides difficile Infection: Are the Data Adequate to Change Practice? | Annals of Pharmacotherapy

Principal Controversies in Vaccine Safety in the United States | CID

Integrating bedside nurses into antibiotic stewardship: A practical approach | ICHE

Oral fosfomycin for the treatment of chronic bacterial prostatitis | JAC

The Association of Antibiotic Stewardship With Fluoroquinolone Prescribing in Michigan Hospitals: A Multi-hospital Cohort Study | CID

Evaluation of Dalbavancin on Length of Stay in Acute Bacterial Skin and Skin Structure Infections | JACCP

Use of a best practice alert linking Clostridoides difficile infection test results to a severity-based treatment order set | ICHE

Effect of changing urine testing orderables and clinician order sets on inpatient urine culture testing: Analysis from a large academic medical center | ICHE

Diagnostic stewardship of C. difficile testing: a quasi-experimental antimicrobial stewardship study | ICHE

Comparing prescribing and dispensing databases to study antibiotic use: a validation study of the Electronic Medical Record Administrative data Linked Database (EMRALD) | JAC

Dolutegravir versus ritonavir-boosted lopinavir both with dual nucleoside reverse transcriptase inhibitor therapy in adults with HIV-1 infection in whom first-line therapy has failed (DAWNING): an open-label, non-inferiority, phase 3b trial | Lancet Infectious Diseases


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Filed Under: Infectious Diseases & Antimicrobial Stewardship

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