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In Case You Missed It: Top ID/Stewardship Journal Articles Trending in March 2019

This article identifies new infectious diseases & antimicrobial stewardship literature released in March 2019. Hot off the press and put together here in one place!



Written By: Bassam Ghanem, Pharm.D., MS, BCPS

Edited By: Timothy P. Gauthier, Pharm.D., BCPS-AQ ID


[Last updated: 2 April 2019]

In this monthly column two pharmacists who utilize Twitter to stay current with antimicrobial stewardship literature (@ABsteward [B.G.] & @IDstewardship [T.G.]) identify some of the top hot off the press articles recently published.

The following are some of the new publications we found most interesting or noteworthy that were released in March of 2019…

1. Fosfomycin for injection (ZTI-01) vs Piperacillin-Tazobactam (PIP-TAZ) for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP): ZEUS, A Phase 2/3 Randomized Trial | CID

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciz181/5370034

ZEUS is a randomized controlled trial that showed IV fosfomycin 6 g q8h was non-inferior to piperacillin-tazobactam 4.5 g IV q8h for a fixed 7-day course of treatment for cUTI and acute pyelonephritis.

2. Use of ribaxamase (SYN-004), a β-lactamase, to prevent Clostridium difficile infection in β-lactam-treated patients: a double-blind, phase 2b, randomised placebo-controlled trial | Lancet infectious

https://www.sciencedirect.com/science/article/pii/S147330991830731X

This RCT showed that in patients treated with intravenous ceftriaxone for lower respiratory tract infections, oral ribaxamase reduced the incidence of C. difficile infections compared with placebo.

3. Association between Antibiotic Use and Hospital-Onset Clostridioides difficile Infection in U.S. Acute Care Hospitals, 2006-2012: an Ecologic Analysis | CID

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciz169/5367464

The largest ecological analysis to date using data from 549 acute care hospitals in the U.S between 2006 and 2012; showed that higher use of third- and fourth-generation cephalosporins and carbapenems were significantly associated with higher rates of Hospital-Onset Clostridioides difficile Infection (HO-CDI) and that temporal changes in antibiotic use correlated with changes in HO-CDI.

4. Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study | Annals of Internal medicine

https://annals.org/aim/fullarticle/2727726/measles-mumps-rubella-vaccination-autism-nationwide-cohort-study

This large Danish cohort study supports that MMR vaccination does not increase the risk for autism, does not trigger autism in susceptible children, and is not associated with clustering of autism cases after vaccination.

5. Cefazolin versus anti-staphylococcal penicillins for the treatment of patients with Staphylococcus aureus bacteremia: a systematic review and meta-analysis | CMI

https://www.sciencedirect.com/science/article/pii/S1198743X19301120

This systematic review and meta-analysis found that cefazolin is at least as effective as anti-staphylococcal penicillins for MSSA bacteremia, and associated with less nephrotoxicity.

6. A randomised controlled trial of matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDITOF-MS) versus conventional microbiological methods for identifying pathogens: impact on optimal antimicrobial therapy of invasive bacterial and fungal infections in Vietnam | Journal of infection

https://www.sciencedirect.com/science/article/abs/pii/S0163445319300957

This RCT concluded that MALDITOF-MS, in the absence of an antimicrobial stewardship programme, did not improve the proportion on optimal antimicrobial therapy at 24 or 48 hours after first growth in a lower-middle income setting with high rates of antibiotic resistance.

7.A Baker’s Dozen of Top Antimicrobial Stewardship Intervention Publications in 2017 | OFID

https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofz133/5419869

The Southeastern Research Group Endeavor (SERGE-45) selected the top 13 peer-reviewed publications in antimicrobial stewardship that detailed an actionable intervention for 2017 using a modified Delphi technique.



Additional New & Notable Publications

One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis | NEJM

Association between urinary community-acquired fluoroquinolone-resistant Escherichia coli and neighbourhood antibiotic consumption: a population-based case-control study | Lancet infectious

Efficacy and safety of intravenous ceftriaxone at home versus intravenous flucloxacillin in hospital for children with cellulitis (CHOICE): a single-centre, open-label, randomised, controlled, non-inferiority trial | Lancet infectious

Open-Label Randomized Trial of Early Clinical Outcomes of Ceftaroline Fosamil Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infections at Risk of Methicillin-Resistant Staphylococcus aureus | Infectious Diseases and Therapy

Antibacterial Envelope to Prevent Cardiac Implantable Device Infection | NEJM

A Trial of a Shorter Regimen for Rifampin-Resistant Tuberculosis | NEJM

Long-Term Outcomes of Partial Oral Treatment of Endocarditis | NEJM

Risk factors for Clostridium difficile infection in pediatric inpatients: A meta-analysis and systematic review | ICHE

An environmental cleaning bundle and health-care-associated infections in hospitals (REACH): a multicentre, randomised trial – The Lancet Infectious Diseases | Lancet infectious

Changes in US Outpatient Antibiotic Prescriptions from 2011-2016 | CID

Antibiotic Therapy for Pseudomonas aeruginosa Bloodstream Infections: How Long is Long Enough? | CID

Antipseudomonal monotherapy or combination therapy for older adults with community-onset pneumonia and multidrug-resistant risk factors: a retrospective cohort study | AJIC

Clinical Data on Daptomycin Plus Ceftaroline Versus Standard of Care Monotherapy in the Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia | AAC

Evaluation of a pharmacist-led penicillin allergy de-labelling ward round: a novel antimicrobial stewardship intervention | JAC

Outcomes from an inpatient beta-lactam allergy guideline across a large US health system | ICHE

The pharmacokinetics of nitrofurantoin in healthy female volunteers: a randomized crossover study | JAC

A methodological comparison of risk scores versus decision trees for predicting drug-resistant infections: A case study using extended-spectrum beta-lactamase (ESBL) bacteremia | ICHE

Impact of obesity on acyclovir-induced nephrotoxicity | OFID

Pharmacists Perceptions of Implementing a Pharmacist Managed Area Under the Concentration Time Curve Guided Vancomycin Dosing Program at a Large Academic Medical Center | JACCP

Towards precision dosing of vancomycin: A systematic evaluation of pharmacometric models for Bayesian forecasting | CMI

Aztreonam plus clavulanate, tazobactam or avibactam for the treatment of metallo-beta-lactamase-producing-Gram negative related infections | AAC

Pharmacodynamic attainment of the synergism of meropenem and fosfomycin combination against Pseudomonas aeruginosa producing metallo-β-lactamase | AAC

Vancomycin Area Under the Curve Dosing and Monitoring at an Academic Medical Center: Transition Strategies and Lessons Learned | JPP

Comparing the selective and co-selective effects of different antimicrobials in bacterial communities | IJAA

Effect of Prescriber Peer Comparison Reports on Fluoroquinolone Use Across a 16 Facility Community Hospital System | JACCP

Impact of CLSI and EUCAST breakpoint discrepancies on reporting of antimicrobial susceptibility and AMR surveillance | CMI

Optimising antibiotic prescribing: Collective approaches to managing a common-pool resource | CMI

Threatened efficiency not autonomy: Prescriber perceptions of an established pediatric antimicrobial stewardship program | ICHE

A Primer on AmpC Beta-Lactamases: Necessary Knowledge for an Increasingly Multidrug-Resistant World | CID

Interplay between beta-lactamases and new beta-lactamase inhibitors | Nature Reviews Microbiology

Methicillin-Resistant Staphylococcus aureus Prosthetic Valve Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management | CMR

Multidrug-resistant Acinetobacter baumannii infections: current evidence on treatment options and role of PK/PD in dose optimization | IJAA

Considerations for Dose Selection and Clinical Pharmacokinetics/Pharmacodynamics for the Development of Antibacterial Agents | AAC

Teaching an Old Class New Tricks: A Novel Semi-Synthetic Aminoglycoside, Plazomicin | Infectious Diseases and Therapy

Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of America | CID

Invasive Aspergillosis in Solid Organ Transplant Recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice | Clinical Transplantation

Infectious Diseases Society of America Position Statement on Telehealth and Telemedicine as Applied to the Practice of Infectious Diseases | CID

Better Sepsis Management Rather Than Fluoroquinolone Prophylaxis for Patients With Cancer-Related Immunosuppression | JCO


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